1. Early increase of neutrophil-to-lymphocyte ratio predicts 30-day mortality in patients with spontaneous intracerebral hemorrhage.
- Author
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Wang F, Xu F, Quan Y, Wang L, Xia JJ, Jiang TT, Shen LJ, Kang WH, Ding Y, Mei LX, Ju XF, Hu SY, and Wu X
- Subjects
- Aged, Aged, 80 and over, Cerebral Hemorrhage therapy, Female, Hospitalization, Humans, Male, Middle Aged, Prognosis, Retrospective Studies, Time Factors, Cerebral Hemorrhage blood, Cerebral Hemorrhage mortality, Leukocyte Count, Lymphocytes, Neutrophils
- Abstract
Aims: To examine whether early rise of neutrophil-to-lymphocyte ratio (NLR) after patient hospitalization correlates with 30-day mortality in patients with spontaneous intracerebral hemorrhage (ICH)., Methods: This retrospective study included all patients receiving treatment for spontaneous ICH between January 2015 and September 2016 at the Jiading District Central Hospital Affiliated Shanghai University of Medicine & Health Sciences in Shanghai, China. NLR was determined at admission (T1), at 24-48 hours (T2) and 5-7 days (T3). NLR and clinicopathologic features were compared between those who survived for >30 days vs not. Multivariate regression was used to identify risk factors for 30-day mortality., Results: A total of 275 subjects were included in the analysis: 235 survived for at least 30 days; the remaining 40 subjects died within 30 days. The patients who died within 30 days had higher ICH score, larger ICH volume, and lower GCS score (all P < 0.05). In comparison with the baseline (NLR
T 1 ), NLR at 24-48 hours (NLRT 2 ) and 5-7 days (NLRT 3 ) was significantly higher in patients who died within 30 days (P < 0.05), but not in patients surviving for >30 days. In the multivariate analysis, the 30-day mortality was associated with both NLRT 2 (OR 1.112, 95%CI 1.032-1.199, P = 0.006) and NLRT 3 (OR 1.163, 95%CI 1.067-1.268, P = 0.001). Spearman correlation analysis showed that both NLRT 2 and NLRT 3 correlated inversely with GCS score and positively with ICH score and ICH volume at the baseline., Conclusions: Early rise of NLR predicts 30-day mortality in patients with spontaneous ICH., (© 2018 The Authors. CNS Neuroscience & Therapeutics Published by John Wiley & Sons Ltd.)- Published
- 2019
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