1. Hereditary cerebral hemorrhage with amyloidosis-Dutch type: a study of fibrinolysis.
- Author
-
Haan J, Kluft C, Leebeek FW, de Bart AC, Buruma OJ, and Roos RA
- Subjects
- Amyloidosis blood, Amyloidosis complications, C-Reactive Protein metabolism, Cerebral Hemorrhage blood, Cerebral Hemorrhage complications, Factor VIII metabolism, Female, Fibrinogen metabolism, Humans, Male, Middle Aged, alpha-2-Antiplasmin metabolism, Amyloidosis genetics, Cerebral Hemorrhage genetics, Fibrinolysis
- Abstract
In view of reported associations between increased bleeding tendency and systemically decreased alpha 2-antiplasmin in patients with systemic amyloid deposition we studied alpha 2-antiplasmin, fibrinogen, C-reactive protein and blood levels of locally produced endothelial hemostasis factors in the acute and quiescent phase in 16 patients with hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D). None of the factors measured in the quiescent phase of the disease was abnormal. In the acute phase, shortly after a stroke, only factor VIII:Ag was evidently elevated. We concluded that systemic abnormalities in the part of the fibrinolysis system studied are not likely to be responsible for multifocal and recurrent cerebral hemorrhages in HCHWA-D. The role of an elevated factor VIII:Ag level in the acute phase is unclear.
- Published
- 1992