1. Acute toxic effects of new synthetic cannabinoid on brain: Neurobehavioral and Histological: Preclinical studies.
- Author
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Ali, Shrouk Mohamed, Kolieb, Eman, Imbaby, Samar, Hagras, Abeer M., Korayem Arafat, Horeya Erfan, Kamel, Eman Mohamed, Abdelshakour, Mohamed A., and Mohammed Ali, Maha Ismail
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SYNTHETIC marijuana , *POISONS , *PYRAMIDAL neurons , *CEREBRAL cortex , *COGNITIVE ability , *INTRAPERITONEAL injections , *NEUROTRANSMITTER receptors - Abstract
The psychoactive effects of new synthetic cannabinoids (SCs), MDMB-4en-PINACA, are being marketed as a blend of herbs and spices. This study aims to determine the behavioral, neurochemical, histopathological, and immunohistochemical alterations associated with the acute toxicity of MDMB-4en-PINACA compounds. Adult male albino rats were administered various toxic doses of the drug (1.5, 3, and 6 mg/kg), and behavioral studies were conducted 2 and 24 h later; animals were then sacrificed. Histopathological and neurochemical examinations were performed. Two hours after intraperitoneal. Intraperitoneal injection of MDMB-4en-PINACA, horizontal movement, the number of stops, and mobility ratio were significantly impaired, along with coordination and balance. In addition, it led to a decline in spatial learning and memory, and neurotransmitter concentrations decreased significantly in a dose-dependent manner. Further examination of the cerebral cortex and hippocampus histopathology revealed pathological degeneration of small pyramidal cells. Thus, these findings revealed that MDMB-4en-PINACA interferes with hippocampal function and impairs cognitive performance, highlighting the cognitive risk associated with SC abuse. [Display omitted] • MDMB-4en-PINACA is a new synthetic cannabinoids compound that decrease the locomotor activity and pain sensation. • Also, it causes an impairment of cognitive performance in rats by interacting with cerebral cortex and hippocampal function. • These findings highlight the risk that abusing synthetic cannabis poses to human cognition. [ABSTRACT FROM AUTHOR] more...
- Published
- 2023
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