8 results on '"Tsukamoto, Hayato"'
Search Results
2. Acute hypoxia impairs posterior cerebral bioenergetics and memory in man.
- Author
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Ando, Soichi, Tsukamoto, Hayato, Stacey, Benjamin S., Washio, Takuro, Owens, Thomas S., Calverley, Thomas A., Fall, Lewis, Marley, Christopher J., Iannetelli, Angelo, Hashimoto, Takeshi, Ogoh, Shigehiko, and Bailey, Damian M.
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MEMORIZATION , *TRANSCRANIAL Doppler ultrasonography , *POSTERIOR cerebral artery , *CEREBRAL circulation , *RESPONSE inhibition , *HYPOXEMIA - Abstract
Hypoxia has the potential to impair cognitive function; however, it is still uncertain which cognitive domains are adversely affected. We examined the effects of acute hypoxia (∼7 h) on central executive (Go/No‐Go) and non‐executive (memory) tasks and the extent to which impairment was potentially related to regional cerebral blood flow and oxygen delivery (CDO2). Twelve male participants performed cognitive tasks following 0, 2, 4 and 6 h of passive exposure to both normoxia and hypoxia (12% O2), in a randomized block cross‐over single‐blinded design. Middle cerebral artery (MCA) and posterior cerebral artery (PCA) blood velocities and corresponding CDO2 were determined using bilateral transcranial Doppler ultrasound. In hypoxia, MCA DO2 was reduced during the Go/No‐Go task (P = 0.010 vs. normoxia, main effect), and PCA DO2 was attenuated during memorization (P = 0.005 vs. normoxia) and recall components (P = 0.002 vs. normoxia) in the memory task. The accuracy of the memory task was also impaired in hypoxia (P = 0.049 vs. normoxia). In contrast, hypoxia failed to alter reaction time (P = 0.19 vs. normoxia) or accuracy (P = 0.20 vs. normoxia) during the Go/No‐Go task, indicating that selective attention and response inhibition were preserved. Hypoxia did not affect cerebral blood flow or corresponding CDO2 responses to cognitive activity (P > 0.05 vs. normoxia). Collectively, these findings highlight the differential sensitivity of cognitive domains, with memory being selectively vulnerable in hypoxia. New Findings: What is the central question of this study?We sought to examine the effects of acute hypoxia on central executive (selective attention and response inhibition) and non‐executive (memory) performance and the extent to which impairments are potentially related to reductions in regional cerebral blood flow and oxygen delivery.What is the main finding and its importance?Memory was impaired in acute hypoxia, and this was accompanied by a selective reduction in posterior cerebral artery oxygen delivery. In contrast, selective attention and response inhibition remained well preserved. These findings suggest that memory is selectively vulnerable to hypoxia. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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3. Concussion history in rugby union players is associated with depressed cerebrovascular reactivity and cognition.
- Author
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Owens, Thomas S., Calverley, Thomas A., Stacey, Benjamin S., Rose, George, Fall, Lewis, Tsukamoto, Hayato, Jones, Gareth, Corkill, Robin, Tuaillon, Edouard, Hirtz, Christophe, Lehmann, Sylvain, Marchi, Nicola, Marley, Christopher J., and Bailey, Damian M.
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INJURY complications ,COGNITION disorder risk factors ,CEREBROVASCULAR disease risk factors ,BIOMARKERS ,SELF-evaluation ,CHEMILUMINESCENCE assay ,CEREBRAL circulation ,BIOAVAILABILITY ,CASE-control method ,NUCLEAR magnetic resonance spectroscopy ,TRANSCRANIAL Doppler ultrasonography ,MOLECULAR biology ,RISK assessment ,CEREBRAL arteries ,HYPOCAPNIA ,NEUROPSYCHOLOGICAL tests ,OXIDATIVE stress ,BRAIN concussion ,DESCRIPTIVE statistics ,ENZYME-linked immunosorbent assay ,MEMORY disorders ,HEMODYNAMICS ,NITRIC oxide ,HYPERCAPNIA ,COGNITIVE testing ,PSYCHOMOTOR disorders ,FREE radicals ,RUGBY football injuries ,DISEASE complications - Abstract
Recurrent contact and concussion in rugby union remains a significant public health concern given the potential increased risk of neurodegeneration in later life. This study determined to what extent prior‐recurrent contact impacts molecular‐hemodynamic biomarkers underpinning cognition in current professional rugby union players with a history of concussion. Measurements were performed in 20 professional rugby union players with an average of 16 (interquartile range [IQR] 13–19) years playing history reporting 3 (IQR 1–4) concussions. They were compared to 17 sex‐age‐physical activity‐and education‐matched non‐contact controls with no prior history of self‐reported concussion. Venous blood was assayed directly for the ascorbate free radical (A•− electron paramagnetic resonance spectroscopy) nitric oxide metabolites (NO reductive ozone‐based chemiluminescence) and select biomarkers of neurovascular unit integrity (NVU chemiluminescence/ELISA). Middle cerebral artery blood flow velocity (MCAv doppler ultrasound) was employed to determine basal perfusion and cerebrovascular reactivity (CVR) to hyper/hypocapnia (CVRCO2Hyper/Hypo). Cognition was assessed by neuropsychometric testing. Elevated systemic oxidative‐nitrosative stress was confirmed in the players through increased A•− (p < 0.001) and suppression of NO bioavailability (p < 0.001). This was accompanied by a lower CVR range (CVRCO2Range; p = 0.045) elevation in neurofilament light‐chain (p = 0.010) and frontotemporal impairments in immediate‐memory (p = 0.001) delayed‐recall (p = 0.048) and fine‐motor coordination (p < 0.001). Accelerated cognitive decline subsequent to prior‐recurrent contact and concussion history is associated with a free radical‐mediated suppression of CVR and neuronal injury providing important mechanistic insight that may help better inform clinical management. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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4. Impaired cerebral blood flow regulation and cognition in male football players.
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Marley, Christopher J., Owens, Thomas S., Tsukamoto, Hayato, Stacey, Benjamin S., Corkill, Robin, and Bailey, Damian M.
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ULTRASONIC encephalography ,BRAIN ,AMATEUR athletes ,CEREBRAL circulation ,PSYCHOLOGY of movement ,TRANSCRANIAL Doppler ultrasonography ,COGNITIVE testing ,BRAIN injuries ,PERFUSION ,CAPNOGRAPHY - Abstract
Football players are at increased risk of neurodegeneration, the likely consequence of repetitive mechanical trauma caused by heading the ball. However, to what extent a history of heading the ball affects cerebral blood flow (CBF) regulation and its potential relationship to cognitive impairment is unknown. To address this, we recruited 16 concussion‐free male amateur football players (age: 25 ± 6 y) with a history of heading the ball (18 ± 6 y) and 18 sex, age, education, and activity‐matched controls with no prior history of contact sport participation or concussion. Cerebral perfusion was measured at rest and in response to both hyper/hypocapnia to determine cerebrovascular reactivity to carbon dioxide (CVRCO2HYPER/HYPO) using transcranial Doppler ultrasound and capnography, with the sum reflecting the cerebral vasomotor range. Cognition and visuomotor coordination were assessed using the Montreal cognitive assessment (MoCA) and the Grooved Pegboard Dexterity Test (GPD), respectively. While no differences in cerebral perfusion were observed (p = 0.938), CVRCO2HYPER/HYPO (p = 0.038/p = 0.025), cerebral vasomotor range (p = 0.002), MoCA (p = 0.027), and GPD performance (dominant hand, P ≤ 0.001) were consistently lower in the players compared to controls. These findings are the first to demonstrate that CBF regulation and cognition are collectively impaired in male football players with history of heading the ball, which may contribute to neurodegeneration. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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5. Integrated respiratory chemoreflex‐mediated regulation of cerebral blood flow in hypoxia: Implications for oxygen delivery and acute mountain sickness.
- Author
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Ogoh, Shigehiko, Washio, Takuro, Stacey, Benjamin S., Tsukamoto, Hayato, Iannetelli, Angelo, Owens, Thomas S., Calverley, Thomas A., Fall, Lewis, Marley, Christopher J., Saito, Shotaro, Watanabe, Hironori, Hashimoto, Takeshi, Ando, Soichi, Miyamoto, Tadayoshi, and Bailey, Damian M.
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MOUNTAIN sickness ,CEREBRAL circulation ,INTERNAL carotid artery ,PATHOLOGICAL physiology ,HYPOXEMIA ,BLOOD flow - Abstract
New Findings: What is the central question of this study?To what extent do hypoxia‐induced changes in the peripheral and central respiratory chemoreflex modulate anterior and posterior cerebral oxygen delivery, with corresponding implications for susceptibility to acute mountain sickness?What is the main finding and its importance?We provide evidence for site‐specific regulation of cerebral blood flow in hypoxia that preserves oxygen delivery in the posterior but not the anterior cerebral circulation, with minimal contribution from the central respiratory chemoreflex. External carotid artery vasodilatation might prove to be an alternative haemodynamic risk factor that predisposes to acute mountain sickness. The aim of the present study was to determine the extent to which hypoxia‐induced changes in the peripheral and central respiratory chemoreflex modulate anterior and posterior cerebral blood flow (CBF) and oxygen delivery (CDO2), with corresponding implications for the pathophysiology of the neurological syndrome, acute mountain sickness (AMS). Eight healthy men were randomly assigned single blind to 7 h of passive exposure to both normoxia (21% O2) and hypoxia (12% O2). The peripheral and central respiratory chemoreflex, internal carotid artery, external carotid artery (ECA) and vertebral artery blood flow (duplex ultrasound) and AMS scores (questionnaires) were measured throughout. A reduction in internal carotid artery CDO2 was observed during hypoxia despite a compensatory elevation in perfusion. In contrast, vertebral artery and ECA CDO2 were preserved, and the former was attributable to a more marked increase in perfusion. Hypoxia was associated with progressive activation of the peripheral respiratory chemoreflex (P < 0.001), whereas the central respiratory chemoreflex remained unchanged (P > 0.05). Symptom severity in participants who developed clinical AMS was positively related to ECA blood flow (Lake Louise score, r = 0.546–0.709, P = 0.004–0.043; Environmental Symptoms Questionnaires‐Cerebral symptoms score, r = 0.587–0.771, P = 0.001–0.027, n = 4). Collectively, these findings highlight the site‐specific regulation of CBF in hypoxia that maintains CDO2 selectively in the posterior but not the anterior cerebral circulation, with minimal contribution from the central respiratory chemoreflex. Furthermore, ECA vasodilatation might represent a hitherto unexplored haemodynamic risk factor implicated in the pathophysiology of AMS. [ABSTRACT FROM AUTHOR]
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- 2021
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6. Contact events in rugby union and the link to reduced cognition: evidence for impaired redox‐regulation of cerebrovascular function.
- Author
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Owens, Thomas S., Calverley, Thomas A., Stacey, Benjamin S., Iannatelli, Angelo, Venables, Lucy, Rose, George, Fall, Lewis, Tsukamoto, Hayato, Berg, Ronan M. G., Jones, Gareth L., Marley, Christopher J., and Bailey, Damian M.
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RUGBY Union football ,COGNITION ,ELECTRON paramagnetic resonance spectroscopy ,COGNITIVE ability ,MONTREAL Cognitive Assessment - Abstract
New Findings: What is the central question of this study?How does recurrent contact incurred across a season of professional rugby union impact molecular, cerebrovascular and cognitive function?What is the main findings and its importance?A single season of professional rugby union increases systemic oxidative–nitrosative stress (OXNOS) confirmed by a free radical‐mediated suppression in nitric oxide bioavailability. Forwards encountered a higher frequency of contact events compared to backs, exhibiting elevated OXNOS and lower cerebrovascular function and cognition. Collectively, these findings provide mechanistic insight into the possible cause of reduced cognition in rugby union subsequent to impairment in the redox regulation of cerebrovascular function. Contact events in rugby union remain a public health concern. We determined the molecular, cerebrovascular and cognitive consequences of contact events during a season of professional rugby. Twenty‐one male players aged 25 (mean) ± 4 (SD) years were recruited from a professional rugby team comprising forwards (n = 13) and backs (n = 8). Data were collected across the season. Pre‐ and post‐season, venous blood was assayed for the ascorbate free radical (A•–, electron paramagnetic resonance spectroscopy) and nitric oxide (NO, reductive ozone‐based chemiluminescence) to quantify oxidative–nitrosative stress (OXNOS). Middle cerebral artery velocity (MCAv, Doppler ultrasound) was measured to assess cerebrovascular reactivity (CVR), and cognition was assessed using the Montreal Cognitive Assessment (MoCA). Notational analysis determined contact events over the season. Forwards incurred more collisions (Mean difference [MD] 7.49; 95% CI, 2.58–12.40; P = 0.005), tackles (MD 3.49; 95% CI, 0.42–6.56; P = 0.028) and jackals (MD 2.21; 95% CI, 0.18–4.24; P = 0.034). Forwards suffered five concussions while backs suffered one concussion. An increase in systemic OXNOS, confirmed by elevated A•– (F2,19 = 10.589, P = 0.004) and corresponding suppression of NO bioavailability (F2,19 = 11.492, P = 0.003) was apparent in forwards and backs across the season. This was accompanied by a reduction in cerebral oxygen delivery (cDO2, F2,19 = 9.440, P = 0.006) and cognition (F2,19 = 4.813, P = 0.041). Forwards exhibited a greater decline in the cerebrovascular reactivity range to changes in PETCO2 (CVRCO2RANG compared to backs (MD 1.378; 95% CI, 0.74–2.02; P < 0.001). [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
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7. Dynamic Cerebral Autoregulation Is Maintained during High-Intensity Interval Exercise.
- Author
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TSUKAMOTO, HAYATO, HASHIMOTO, TAKESHI, OLESEN, NIELS D., PETERSEN, LONNIE G., SØRENSEN, HENRIK, SECHER, NIELS H., NIELSEN, HENNING B., and OGOH, SHIGEHIKO
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ARTERIES , *BLOOD pressure , *CATHETERIZATION , *CEREBRAL arteries , *CEREBRAL circulation , *EXERCISE physiology , *TIME , *TRANSCRANIAL Doppler ultrasonography , *EMPLOYEES' workload , *BRACHIAL artery , *HIGH-intensity interval training - Abstract
Introduction: High-intensity interval exercise (HIIE) is more effective at increasing metabolic and cardiovascular health compared with moderate-intensity continuous exercise for patients with cardiovascular disease, but exhaustive high-intensity continuous exercise attenuates dynamic cerebral autoregulation (CA). This study assessed the effect of HIIE on dynamic CA. Methods: Nine healthy men (age, 24 ± 3 yr; mean ± SD) warmed up at 50%–60% maximal workload (W max) for 5 min before HIIE including four 4-min bouts of exercise at 80%–90% W max interspaced by four 3-min bouts at 50% to 60% W max. Transcranial Doppler determined middle cerebral artery mean blood velocity (MCA V mean), and brachial artery catheterization determined mean arterial pressure (MAP). Dynamic CA was evaluated by transfer function analysis of changes in MAP and MCA V mean. Results: The HIIE increased MAP (from 92 ± 9 to 104 ± 10 mm Hg; P < 0.0125), whereas MCA V mean did not change. Transfer function phase increased and coherence decreased during HIIE (P < 0.0125 vs rest, respectively), whereas gain was unchanged. Conclusions: The results suggest that dynamic CA is unaffected during HIIE, indicating that the brain is protected from fluctuations in MAP. Thus, we propose that HIIE may be beneficial for brain-related health as maintenance of cerebral perfusion in contrast to high-intensity continuous exercise. [ABSTRACT FROM AUTHOR]
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- 2019
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8. Effect of Exercise on Brain Health: The Potential Role of Lactate as a Myokine.
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Hashimoto, Takeshi, Tsukamoto, Hayato, Ando, Soichi, and Ogoh, Shigehiko
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HIGH-intensity interval training ,LACTATES ,TREADMILL exercise ,LACTATION ,VASCULAR endothelial growth factors ,EXERCISE intensity - Abstract
It has been well established in epidemiological studies and randomized controlled trials that habitual exercise is beneficial for brain health, such as cognition and mental health. Generally, it may be reasonable to say that the physiological benefits of acute exercise can prevent brain disorders in late life if such exercise is habitually/chronically conducted. However, the mechanisms of improvement in brain function via chronic exercise remain incompletely understood because such mechanisms are assumed to be multifactorial, such as the adaptation of repeated acute exercise. This review postulates that cerebral metabolism may be an important physiological factor that determines brain function. Among metabolites, the provision of lactate to meet elevated neural activity and regulate the cerebrovascular system and redox states in response to exercise may be responsible for exercise-enhanced brain health. Here, we summarize the current knowledge regarding the influence of exercise on brain health, particularly cognitive performance, with the underlying mechanisms by means of lactate. Regarding the influence of chronic exercise on brain function, the relevance of exercise intensity and modality, particularly high-intensity interval exercise, is acknowledged to induce "metabolic myokine" (i.e., lactate) for brain health. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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