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Your search keyword '"postsynaptic receptor"' showing total 3 results
Start Over Descriptor "postsynaptic receptor" Topic central nervous system
3 results on '"postsynaptic receptor"'

1. De presynaptische α-receptor, een mogelijk aangrijpingspunt voor farmaca

Subjects
oxymetazoline, alpha adrenergic receptor, alpha dimethyl meta tyramine, noradrenalin, corbadrine, phenoxybenzamine, presynaptic receptor, review, cocaine, tolazoline, adrenalin, tyramine, reserpine, azapetine, dihydroergotamine, mianserin, nebidrazine, methoxamine, survey, yohimbine, clonidine, prazosin, naphazoline, clozapine, tramazoline, behavior, animal model, autonomic nervous system, nervous system, blood pressure, postsynaptic receptor, phentolamine, biological model, central nervous system, phenylephrine, unclassified drug, noradrenalin h 3, metirosine, guanethidine, 3 hydroxybenzylhydrazine, DOPA, cardiovascular system, desipramine, piperoxan
Published
1979

2. De presynaptische α-receptor, een mogelijk aangrijpingspunt voor farmaca

Subjects
oxymetazoline, alpha adrenergic receptor, alpha dimethyl meta tyramine, noradrenalin, corbadrine, phenoxybenzamine, presynaptic receptor, review, cocaine, tolazoline, adrenalin, tyramine, reserpine, azapetine, dihydroergotamine, mianserin, nebidrazine, methoxamine, survey, yohimbine, clonidine, prazosin, naphazoline, clozapine, tramazoline, behavior, animal model, autonomic nervous system, nervous system, blood pressure, postsynaptic receptor, phentolamine, biological model, central nervous system, phenylephrine, unclassified drug, noradrenalin h 3, metirosine, guanethidine, 3 hydroxybenzylhydrazine, DOPA, cardiovascular system, desipramine, piperoxan
Published
1979

3. Captopril impairs the vascular smooth muscle contraction mediated by postsynaptic α2-adrenoceptors in the pithed rat

Author

Adriaan De Jonge, Bob Wilffert, Hans O. Kalkman, Jacques C.A. Van Meel, Martin J.M.C. Thoolen, Pieter B.M.W.M. Timmermans, Pieter A. Van Zwieten, Methods in Medicines evaluation & Outcomes research (M2O), and Reproductive Origins of Adult Health and Disease (ROAHD)

Subjects
Male, Vascular smooth muscle, alpha adrenergic receptor, drug response, Adrenergic, sotalol, spinal animal, rauwolscine, smooth muscle, Norepinephrine, Postsynaptic potential, renin angiotensin aldosterone system, rat, Chemistry, blood pressure, Smooth muscle contraction, postsynaptic receptor, Receptors, Adrenergic, captopril, endocrine system, Spinal Cord, medicine.symptom, Vascular smooth muscle contraction, hormones, hormone substitutes, and hormone antagonists, medicine.drug, circulatory and respiratory physiology, medicine.medical_specialty, kidney, Proline, smooth muscle contractility, noradrenalin, alpha adrenergic receptor stimulating agent, animal experiment, Internal medicine, medicine, Prazosin, Animals, peripheral vascular system, Pharmacology, prazosin, Rats, Inbred Strains, Captopril, Receptors, Adrenergic, alpha, central nervous system, Rats, Endocrinology, Vasoconstriction, vascular smooth muscle, Synapses, cardiovascular system
Abstract

Since two different types of α-adrenoceptors (α1- and α2-) subserve vasoconstriction in pithed rats and noradrenaline behaves as a non-selective agonist of both receptors (for review see Timmerman and van Zwieten, 1981), we have investigated this interaction between noradrenaline and captopril in more detail to identify the class of α-adrenoceptor involved. This study confirms the findings reported recently (Antonaccio and Kerwin, 1981; Clough et al., 1981) that captopril inhibits postjunctional vasocontrictor responses to noradrenaline in pithed rats. However, captopril interfered with the vasoconstriction elicited by noradrenaline only in those animals in which the vascular postsynaptic α2-adrenoceptor system could be triggered (saline-and prazosin-treated rats). Captopril was without effect after removal of the contribution of post-synaptic α2-adrenoceptor stimulation to the in vivo vascular smooth muscle contraction due to (-)-noradrenaline (rauwolscine-treated rats). These results indicate that captopril selectively impairs the vasoconstriction subserved in vivo by postjunctinal α2-adrenoceptors. The vasoconstrictor process initiated by α1-adrenoceptor activation is not affected by captopril.

Published
1981

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