1. MicroRNA-410 promotes cell proliferation by targeting BRD7 in non-small cell lung cancer.
- Author
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Li D, Yang Y, Zhu G, Liu X, Zhao M, Li X, and Yang Q
- Subjects
- 3' Untranslated Regions genetics, Adult, Base Sequence, Blotting, Western, Carcinoma, Non-Small-Cell Lung metabolism, Carcinoma, Non-Small-Cell Lung pathology, Cell Line, Cell Line, Tumor, Cell Movement genetics, Chromosomal Proteins, Non-Histone metabolism, Female, Gene Expression Regulation, Neoplastic, Humans, Lung Neoplasms metabolism, Lung Neoplasms pathology, Male, Middle Aged, Proto-Oncogene Proteins c-akt genetics, Proto-Oncogene Proteins c-akt metabolism, RNA Interference, Reverse Transcriptase Polymerase Chain Reaction, Sequence Homology, Nucleic Acid, Signal Transduction genetics, Carcinoma, Non-Small-Cell Lung genetics, Cell Proliferation drug effects, Chromosomal Proteins, Non-Histone genetics, Lung Neoplasms genetics, MicroRNAs genetics
- Abstract
miR-410 acts as an oncogene or tumor suppressor gene in some malignancies. However, its role in NSCLC is still unknown. In this study, we showed that the expression of miR-410 was up-regulated in both human NSCLC tissues and cells. Overexpression of miR-410 promoted cell proliferation, migration, and invasion of NSCLC. In addition, bromodomain-containing protein 7 (BRD7) was a direct target of miR-410. MiR-410-mediated downregulation of BRD7 led to increase Akt phosphorylation. Inhibition of Akt phosphorylation can rescue the effect of miR-410 on NSCLC cell. The expression of BRD7 was downregulated in NSCLC and was inversely expressed with miR-410 in NSCLC. Our data provided new knowledge regarding the role of miR-410 in the lung cancer progression., (Copyright © 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.)
- Published
- 2015
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