1. Effect of Polypeptides on Cell Proliferation and Apoptosis during Aging.
- Author
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Ryzhak AP, Chalisova NI, Lin'kova NS, Nichik TE, Dudkov AV, Kolchina NV, Ryzhak GA, and Khalimov RI
- Subjects
- Amino Acid Sequence, Animals, Blood Vessels chemistry, Blood Vessels cytology, Bronchi chemistry, Bronchi cytology, Caspase 3 genetics, Caspase 3 metabolism, Female, Gene Expression Regulation, Ki-67 Antigen genetics, Ki-67 Antigen metabolism, Kidney chemistry, Kidney cytology, Male, Muscles chemistry, Muscles cytology, Organ Specificity, Ovary chemistry, Ovary cytology, Peptides isolation & purification, Rats, Rats, Wistar, Retina chemistry, Retina cytology, Testis chemistry, Testis cytology, Tumor Suppressor Protein p53 genetics, Tumor Suppressor Protein p53 metabolism, Aging physiology, Apoptosis drug effects, Cell Proliferation drug effects, Peptides pharmacology, Tissue Culture Techniques
- Abstract
Polypeptide complexes derived from the bronchi, blood vessels, muscles, kidneys, ovaries, testes, and retina stimulated the processes of cell renewal in organotypic cultures of the corresponding organs of young and old animals. A correlation between the intensity of regeneration and animal' age was revealed. The polypeptide complexes reduced the expression of apoptotic factors p53 and caspase 3 and increased the expression of proliferation protein Ki-67. These results provide the basis for further study of the polypeptide complexes as stimulators of regenerative processes in different tissues during ageing.
- Published
- 2017
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