1. Litchi seed extract inhibits epidermal growth factor receptor signaling and growth of Two Non-small cell lung carcinoma cells.
- Author
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Chung YC, Chen CH, Tsai YT, Lin CC, Chou JC, Kao TY, Huang CC, Cheng CH, and Hsu CP
- Subjects
- Apoptosis drug effects, Carcinoma, Non-Small-Cell Lung drug therapy, Carcinoma, Non-Small-Cell Lung genetics, Carcinoma, Non-Small-Cell Lung physiopathology, Cell Cycle drug effects, Cell Line, Tumor, ErbB Receptors genetics, Humans, Lung Neoplasms drug therapy, Lung Neoplasms genetics, Lung Neoplasms physiopathology, Carcinoma, Non-Small-Cell Lung metabolism, Cell Proliferation drug effects, ErbB Receptors metabolism, Litchi chemistry, Lung Neoplasms metabolism, Seeds chemistry, Signal Transduction drug effects
- Abstract
Background: Litchi seeds possess rich amounts of phenolics and have been shown to inhibit proliferation of several types of cancer cells. However, the suppression of EGFR signaling in non-small cell lung cancer (NSCLC) by litchi seed extract (LCSE) has not been fully understood., Methods: In this study, the effects of LCSE on EGFR signaling, cell proliferation, the cell cycle and apoptosis in A549 adenocarcinoma cells and NCI- H661 large-cell carcinoma cells were examined., Results: The results demonstrated that LCSE potently reduced the number of cancer cells and induced growth inhibition, cell-cycle arrest in the G1 or G2/M phase, and apoptotic death in the cellular experiment. Only low cytotoxicity effect was noted in normal lung MRC-5 cells. LCSE also suppressed cyclins and Bcl-2 and elevated Kip1/p27, Bax and caspase 8, 9 and 3 activities, which are closely associated with the downregulation of EGFR and its downstream Akt and Erk-1/-2 signaling., Conclusion: The results implied that LCSE suppressed EGFR signaling and inhibited NSCLC cell growth. This study provided in vitro evidence that LCSE could serve as a potential agent for the adjuvant treatment of NSCLC.
- Published
- 2017
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