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15 results on '"Kuzin AM"'

2. [Effects of ubiquinone-9 on lipids of nuclei and chromatin of the rat liver under continuous irradiation].

Author

Kulagina TP, Kolomiĭtseva IK, Obol'nikova EA, Samokhvalov GI, and Kuzin AM

Subjects
Animals, Cell Nucleus drug effects, Cell Nucleus radiation effects, Cholesterol analysis, Cholesterol radiation effects, Chromatin drug effects, Chromatin radiation effects, Chromatography, Thin Layer, Fatty Acids, Nonesterified analysis, Fatty Acids, Nonesterified radiation effects, In Vitro Techniques, Lipids radiation effects, Male, Phospholipids analysis, Phospholipids radiation effects, Radiation Dosage, Rats, Rats, Wistar, Cell Nucleus chemistry, Chromatin chemistry, Lipids analysis, Liver drug effects, Liver radiation effects, Ubiquinone pharmacology
Abstract

The influence of continuous gamma irradiation on the lipids of nuclei and chromatin of rat liver at a dose-rate of 0,129 Gy/day for 155 days (a total dose of 20 Gy) and by feeding of ubiquinone-9 has been studied. The amount of phosphatidylcholine with phosphatidylserine and phosphatidyl-ethanolamine in liver nuclei of irradiated rats was found to increase. Ubiquinone-9 had a normalizing effect. A decrease of cardiolipin was observed in the liver chromatin of irradiated rats. The amount of free fatty acids had a tendency to decrease in homogenate, nuclei and liver chromatin of irradiated rats. Ubiquinone was found to increase the amount of free fatty acids up to the control level. The amount of cholesterol in nuclei was increased after irradiation and that in chromatin tended to rise. Ubiquinone-9 significantly decreased the amount of cholesterol in nuclei and chromatin of irradiated rats.

Published
1992

4. [Radiation effects on the permeability of thymocyte nuclear membranes].

Author

Tarshis MA, Kuzin AM, and Burd GI

Subjects
Animals, Carbon Isotopes, Glucose metabolism, NAD metabolism, Nucleosides metabolism, Nucleotides metabolism, Proteins metabolism, Rats, Thymus Gland cytology, Cell Nucleus radiation effects, Membranes radiation effects, Permeability, Radiation Effects, Thymus Gland radiation effects
Published
1969

11. Role of "orthophenol--orthoquinone" system in the initial mechanisms of action of ionizing radiation on the organism.

Author

Kuzin AM, Plyshevskaya EG, Kopylov VA, Ivanitskaya EA, Lebedeva NE, Kolomiitseva IK, Tokarskaya VI, and Mel'nikova SK

Subjects
Animals, Catechols metabolism, Chlorogenic Acid analysis, Cinnamates analysis, DNA biosynthesis, In Vitro Techniques, Leukocyte Count, Plants, Edible metabolism, Rats, Spectrum Analysis, Thymus Gland cytology, Cell Nucleus metabolism, Phenols biosynthesis, Quinones biosynthesis, Radiation Effects, Tyrosine metabolism, Tyrosine Decarboxylase metabolism
Published
1966

15. On the role of the orthophenol-orthoquinone system in the initial effect of ionizing radiation on the organism

Author

V.I. Tokarskaya, Kuzin Am, V.A. Kopylov, N.E. Lebedeva, Mel'nikova Sk, I.K. Kolomijtseva, E.A. Ivanitskaya, and E.G. Plyshevskaya

Subjects
In Vitro Techniques, Ionizing radiation, chemistry.chemical_compound, Leukocyte Count, Phenols, Caffeic acid, Animals, Irradiation, Tyrosine, Cell Nucleus, Chromatography, Aqueous solution, Acridine orange, Radiochemistry, Quinones, General Medicine, DNA, Tyrosine Decarboxylase, Fluorescence, Rats, Radiation Effects, chemistry, Biochemistry, Cinnamates, Spectrophotometry, Chlorogenic Acid
Abstract

SummaryInvestigating the rate of oxidation of tyrosine by enzyme in a radiation field of low intensity, we showed that the rate of this reaction was 5–10 times increased at 200–1000 r doses. The increase was partially the result of radiochemical oxidation of tyrosine. The use of spectrophotometrical and chemical methods illustrate that isolated native cell nuclear actively absorb products of tyrosine oxidation (namely, orthoquinones) from aqueous solution.The change in fluorescence of thymus nuclei in the presence of AO in the case of action of orthoquinones is analogous to that in case of ionizing radiation. Using this test we showed that orthoquinones were present in the extracts from irradiated plants and rat liver. Formation of orthoquinones and increase of such orthophenols as chlorogenic and caffeic acids was illustrated quantitively by paper and column chromatography.Orthophenols–orthoquinones formed in irradiated plant tissues (extracted 24 hours after 15 kr irradiation) are absorbed by roots of n...

Published
1966

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