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Co(II), Ni(II), Zn(II), and Cd(II) complexes were synthesized from a Schiff base ligand, benzyl-2-(1-(thiophen-2-yl)propylidene)hydrazine-1-carbodithioate (BTPHC), by conventional as well as microwave irradiation methods. The ligand and its metal complexes were characterized by spectroscopic techniques (FT-IR, UV-vis, mass spectrometry, and 1H NMR) and powder X-ray diffraction. Based on magnetic measurements and spectral data, octahedral environments for Co(II) and Ni(II) complexes and tetrahedral environments for Zn(II) and Cd(II) complexes are proposed. The metal(II) complexes were active toward bacterial and fungal strains. Antidiabetic studies showed that the Cd(II) complex possesses greater potential as an antidiabetic agent than the other metal complexes and the ligand. Antioxidant studies indicate that the Zn(II) and Cd(II) complexes possess high radical scavenging activities. The synthesized ligand and metal(II) complexes were screened for their anticancer properties against two human cancer cell lines MCF-7 and HeLa using an MTT cell viability assay. The Ni(II) complex excelled in halting the proliferation of HeLa and MCF-7 cancer cell lines with IC50 values of 46.63 µM and 80.90 µM, respectively, whereas it displayed insignificant cytotoxicity against the human normal embryonic kidney cell line (HEK293) with IC50 = 300.41 µM. [ABSTRACT FROM AUTHOR]

This paper includes the synthesis of a Schiff base ligand and its palladium(II) complexes by conventional and green microwave-assisted techniques. They were characterized by conductivity measurements, mass spectrometry, FTIR, electronic spectroscopy, 1H NMR, and X-ray powder diffraction techniques. Based on analytical and spectral data, a square planar geometry was proposed for the metal complexes. The ligand(LH) and its metal complex[Pd(L)2] were screened for antimicrobial activity against pathogenic bacterial(Escherichia coli, Staphylococcus aureus) and fungal(Aspergillus niger, Penicillium chrysogenum) strains. Ciprofloxacin and Ketoconazole were used as standard drugs for antibacterial and antifungal activities respectively. The compounds showed moderate activity. The starting material(PdCl2), ligand(LH), and the metal complex [Pd(L)2] were screened for in vitro cytotoxic activity by MTT assay against cancerous cell lines (HeLa, MCF-7). Cisplatin was used as the standard drug. The metal complex, [Pd(L)2] was also screened for cytotoxic activity against normal cell line(HEK 293) to determine the selectivity index. The values of S.I(3.70-4.58) indicated that the complex [Pd(L)2] was more sensitive towards cancerous cell lines than normal cell line and may be studied further to assess its potential as cytotoxic agent. [ABSTRACT FROM AUTHOR]