1. Assignment of the gene for galactokinase to human chromosome 17 and its regional localisation to band q21-22
- Author
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Raju Kucherlapati, E.A. Nichols, Richard E. Giles, Frank H. Ruddle, K. Willecke, R.P. Creagan, S.M. Elsevier, and J.K. McDougall
- Subjects
Genetics ,Multidisciplinary ,Phosphotransferases ,Somatic Cell Genetics ,Chromosome Mapping ,Chromosome ,Hybrid Cells ,Biology ,Galactokinase ,Cell Line ,Clone Cells ,Chromosome 17 (human) ,Leloir pathway ,Mice ,Genes ,Thymidine kinase ,Animals ,Humans ,Human genome ,Gene ,Chromosomes, Human, 16-18 - Abstract
PROGRESS in somatic cell genetics now allows more rapid and precise localisation of genes within the human genome. A large number of mouse × human hybrid cell lines are available, permitting the investigator to choose, for phenotype assay, lines with a particular reduced human chromosome complement. An increasingly large number of hybrid lines carrying rearranged chromosomes are also becoming available for regional localisation studies. We have used such hybrid cell lines to assign a gene coding for galactokinase (EC 2.7.1.6) to human chromosome 17 and to further localise the gene to band 21–22 on the long arm of the chromosome. Results from this study have provided new information Regarding the functioning of the genes coding for the Leloir pathway enzymes in man1, and have revealed a relatively close and potentially useful linkage between the genes for galactokinase and for thymidine kinase (EC 2.7.1.21).
- Published
- 1974
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