1. NIR-II-triggered doxorubicin release for orthotopic bladder cancer chemo-photothermal therapy
- Author
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Zhiduo Sun, Weiyun Zhang, Zhichao Ye, Li Yuan, Manli Fu, Xiaoming Liu, Huageng Liang, and Heyou Han
- Subjects
Chitosan ,Photothermal Therapy ,Urinary Bladder ,Mice, Nude ,Hyperthermia, Induced ,Phototherapy ,Mice ,Drug Liberation ,Drug Delivery Systems ,Urinary Bladder Neoplasms ,Doxorubicin ,Cell Line, Tumor ,Animals ,Nanoparticles ,General Materials Science - Abstract
Intravesical instillation has been widely utilized for bladder cancer treatment in clinic. However, due to the bladder mucosal barrier, its poor penetration efficiency and drug utilization limit the clinical therapeutic effectiveness and result in a high recurrence rate. Therefore, designing an efficient and controllable drug delivery nanoplatform is of great significance for bladder cancer treatment. Non-invasive therapy based on near-infrared-II (NIR-II) photothermal therapy (PTT) conduces to overcome bladder mucosal barrier and enhance drug delivery. Also, the photothermal nanomaterials, Au Hollow Nanorods (AuHNRs), demonstrate strong photothermal properties and drug loading capacity. Herein, a quaternized chitosan
- Published
- 2022