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Your search keyword '"Mengwen Yi"' showing total 2 results
Start Over Author "Mengwen Yi" Topic cell line, tumor
2 results on '"Mengwen Yi"'

1. A photo-activated aptamer-drug conjugate for targeted drug delivery

Author

Jing Liu, Xiangjun Liu, Mengwen Yi, Yue Sun, Tao Bing, Nan Zhang, and Dihua Shangguan

Subjects
Cytotoxins, Metals and Alloys, Oligonucleotides, General Chemistry, Aptamers, Nucleotide, Catalysis, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Naphthalimides, Drug Delivery Systems, Pharmaceutical Preparations, Doxorubicin, Cell Line, Tumor, Materials Chemistry, Ceramics and Composites
Abstract

A photo-activated aptamer-drug conjugate, HG1-9-DNP, was developed based on an aptamer HG1-9 and a photolabile naphthalimide derivative DNP. HG1-9-DNP could be internalized into cells mediated by TfR, then photocleaved, and released a promising cytotoxic agent, DNNH, which arrested the cell cycle at the G2/M phase, resulting in high photo-induced cytotoxicity.

Published
2022

2. A 4-aminonaphthalimide-based fluorescent traceable prodrug with excellent photoinduced cytotoxicity

Author

Lingling Zhang, Dihua Shangguan, Xiangjun Liu, Jing Liu, Mengwen Yi, Shilong Zhong, Tao Bing, and Nan Zhang

Subjects
Light, Chemistry, Metals and Alloys, Antineoplastic Agents, Phthalimides, General Chemistry, Prodrug, Anticancer drug, Combinatorial chemistry, Fluorescence, Catalysis, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, chemistry.chemical_compound, Cell Line, Tumor, Materials Chemistry, Ceramics and Composites, Humans, Camptothecin, Prodrugs, Cytotoxicity, Derivative (chemistry), Blue light
Abstract

A blue light activated anti-cancer prodrug, NST, was designed based on a photoactive 4-aminonaphthalimide derivative and an anticancer drug, 10-hydroxycamptothecin. NST was hard to be taken up by living cells and showed negligible dark cytotoxicity. The irradiation caused photocleavage of NST and resulted in high cytotoxicity.

Published
2021

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