1. In Vitro Cytotoxic Effects and Mechanisms of Action of Eleutherine Isolated from
- Author
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Victoria Mae Tsuruzaki, Shinkai, Izana Marize Oliveira, Sampaio, Eline Gomes, Dos Santos, Adan Jesús, Galué-Parra, Dionisia Pelaes, Ferreira, Drielly Dayanne Monteiro Santos, Baliza, Neidiane Farias, Ramos, Raphael Sanzio, Pimenta, Rommel Mario Rodriguez, Burbano, Chubert Bernardo Castro, Sena, Barbarella Matos, Macchi, Irlon Maciel, Ferreira, Edilene Oliveira, Silva, and José Luiz Martins, do Nascimento
- Subjects
Brain Neoplasms ,Cell Line, Tumor ,Animals ,Antineoplastic Agents ,Apoptosis ,Glioma ,Proto-Oncogene Proteins c-akt ,Rats ,Cell Proliferation - Abstract
Gliomas are the most common primary malignant brain tumors in adults, and have a poor prognosis, despite the different types of treatment available. There is growing demand for new therapies to treat this life-threatening tumor. Quinone derivatives from plants have received increased interest as potential anti-glioma drugs, due to their diverse pharmacologic activities, such as inhibiting cell growth, inflammation, tumor invasion, and promoting tumor regression. Previous studies have demonstrated the anti-glioma activity of
- Published
- 2022