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Start Over Author "Paulini K" Topic cell division
3 results on '"Paulini K"'

2. The influence of D-penicillamine on cell proliferation. II. Quantitative investigations during a chronic proliferative inflammation in a model granuloma.

Author

Paulini K, Bock G, and Sonntag W

Subjects
Animals, Body Weight drug effects, Collagen metabolism, DNA metabolism, Granuloma pathology, Male, Rats, Rats, Inbred Strains, Time Factors, Cell Division drug effects, Inflammation pathology, Penicillamine pharmacology
Abstract

The influence of D-penicillamine (DPA) on a defined chronic proliferative inflammation in a model granuloma was tested in a long-term experiment. A change in collagen metabolism was detected during the three weeks of DPA administration, whereas the proliferation of the fibroblast population remained unaffected.

Published
1977

3. The influence of D-penicillamine on cell proliferation. I. Quantitative investigations during an acute exudative inflammation in a model granuloma.

Author

Paulini K, Bock G, and Sonntag W

Subjects
Animals, Body Weight drug effects, Collagen metabolism, DNA metabolism, Exudates and Transudates cytology, Fibroblasts metabolism, Inflammation metabolism, Male, Rats, Time Factors, Cell Division drug effects, Inflammation pathology, Penicillamine pharmacology
Abstract

The influence of D-penicillamine (DPA) administration on a defined acute exudative inflammation in a model granuloma was investigated in a short-term experiment. The results indicate that DPA administration influences the metabolism of collagen but does not influence the proliferation behaviour of the fibroblasts. A significant increase in the number of fibroblasts can be explained in terms of an interaction of the loss of the soluble collagen with the number of fibroblasts necessary to maintain the total collagen level constant.

Published
1977

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