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Start Over Author "Miettinen, Paivi J" Topic cell differentiation -- physiological aspects
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1. Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor

Author

Miettinen, Paivi J., Berger, Joel E., Meneses, Juanito, Phung, Yume, Pedersen, Roger A., Werb, Zena, and Derynck, Rik

Subjects
Epidermal growth factor -- Receptors, Cell differentiation -- Physiological aspects, Embryology -- Physiological aspects, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Mice lacking both the epidermal growth factor (EGF) and its receptor exhibit retardation in growth and epithelial immaturity as a result of which there are gastrointestinal, lung, skin and other disorders that are similar to human diseases after premature birth. EGF is responsible for opening of the eyelids and its receptor is a tyrosine kinase receptor that is found in large quantities in mammals. The receptor is activated when it binds EGF or transforming growth factor-alpha, that results in induction of cell differentiation and proliferation. more...

Published
1995

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