1. Regulation of the Macroautophagic Machinery, Cellular Differentiation, and Immune Responses by Human Oncogenic γ-Herpesviruses.
- Author
-
Münz C
- Subjects
- Animals, B-Lymphocytes cytology, B-Lymphocytes immunology, B-Lymphocytes metabolism, Herpesvirus 8, Human immunology, Humans, Lymphopoiesis, Viral Proteins immunology, Viral Proteins metabolism, Cell Differentiation immunology, Epstein-Barr Virus Infections immunology, Epstein-Barr Virus Infections virology, Herpesvirus 4, Human immunology, Host-Pathogen Interactions immunology, Macroautophagy immunology, Tumor Virus Infections immunology, Tumor Virus Infections virology
- Abstract
The human γ-herpesviruses Epstein-Barr virus (EBV) and Kaposi sarcoma-associated herpesvirus (KSHV) encode oncogenes for B cell transformation but are carried by most infected individuals without symptoms. For this purpose, they manipulate the anti-apoptotic pathway macroautophagy, cellular proliferation and apoptosis, as well as immune recognition. The mechanisms and functional relevance of these manipulations are discussed in this review. They allow both viruses to strike the balance between efficient persistence and dissemination in their human hosts without ever being cleared after infection and avoiding pathologies in most of their carriers.
- Published
- 2021
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