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Your search keyword '"Philip C. Caron"' showing total 6 results
Start Over Author "Philip C. Caron" Topic cell biology
6 results on '"Philip C. Caron"'

1. Brentuximab Vedotin Combined with Chemotherapy in Newly Diagnosed, Early-Stage, Unfavorable-Risk Hodgkin Lymphoma: Extended Follow-up with Evaluation of Baseline Metabolic Tumor Volume and PET2

Author

Robert Stuver, Laure Michaud, Carla Casulo, Ranjana H. Advani, Elizabeth L. Budde, Paul M. Barr, Connie Lee Batlevi, Philip C Caron, Louis S. Constine, Savita Dandapani, Pamela Drullinsky, Jonathan W. Friedberg, Clare Grieve, Audrey Hamilton, Paul A. Hamlin, Richard Hoppe, Steven M. Horwitz, Niloufer Khan, Matthew J. Matasar, Ariela Noy, M.Lia Palomba, Heiko Schoder, David J. Straus, Shreya Vemuri, Joachim Yahalom, Joanna C. Yang, Anas Younes, Andrew D. Zelenetz, Craig H. Moskowitz, Anita Kumar, and Alison J. Moskowitz

Subjects
Immunology, Cell Biology, Hematology, Biochemistry
Published
2022

2. Molecular Profiling across Lymphoma Subtypes Using MSK-Impact Next Generation Sequencing

Author

Connie Lee Batlevi, Esther Drill, Michelle Okwali, Ryan Ptashkin, Philip C Caron, Zachary D. Epstein-Peterson, Lorenzo Falchi, Audrey Hamilton, Paul A. Hamlin, Steven M. Horwitz, Andrew M. Intlekofer, William T. Johnson, Niloufer Khan, Anita Kumar, Jennifer Kimberly Lue, Matthew J. Matasar, Alison J. Moskowitz, Ariela Noy, Colette Owens, Maria Lia Palomba, David J. Straus, Santosha Vardhana, Andrew D. Zelenetz, Maria E. Arcila, Ahmet Dogan, Venkatraman Seshan, Gilles Salles, Ahmet Zehir, and Anas Younes

Subjects
Immunology, Cell Biology, Hematology, Biochemistry
Published
2022

3. Immune Signature of Pembrolizumab Plus Gemcitabine, Vinorelbine, and Liposomal Doxorubicin As Second-Line Therapy for Relapsed or Refractory Classical Hodgkin Lymphoma

Author

Beatriz Wills, Nivetha Ganesan, Gunjan L. Shah, Phillip Wong, Kimon V. Argyropoulos, Filiz Sen, Ahmet Dogan, David J. Straus, Ariela Noy, Anita Kumar, Heiko Schoder, Laure Michaud, Maria Lia Palomba, Lorenzo Falchi, Oscar B Lahoud, Paul A. Hamlin, Joachim Yahalom, William T. Johnson, Andrew D. Zelenetz, Andrew M. Intlekofer, Colette Owens, Connie Lee Batlevi, Audrey Hamilton, Philip C Caron, Steven M. Horwitz, Natasha Galasso, Helen Hancock, Theresa Davey, Alayna Santarosa, Leslie Perez, Charisse Capadona, Brittney Munayirji, Matthew J. Matasar, Georgios Pongas, Ellie Casper, Gilles Salles, Craig H. Moskowitz, Santosha Vardhana, and Alison J. Moskowitz

Subjects
Immunology, Cell Biology, Hematology, Biochemistry
Published
2022

4. Characterization of a Large Cohort of Patients with Nodal Marginal Zone Lymphoma Shows Prolonged Survival, Time-to-Treatment, and Time-to-Transformation

Author

Robert Stuver, Esther Drill, David Qualls, Michelle Okwali, Connie Lee Batlevi, Philip C Caron, Zachary D. Epstein-Peterson, Lorenzo Falchi, Audrey Hamilton, Paul A. Hamlin, Steven M. Horwitz, Andrew M. Intlekofer, William T. Johnson, Niloufer Khan, Oscar B Lahoud, Jennifer Kimberly Lue, Matthew J. Matasar, Alison J. Moskowitz, Ariela Noy, M.Lia Palomba, Santosha Vardhana, Andrew D. Zelenetz, Gilles Salles, and David J. Straus

Subjects
Immunology, Cell Biology, Hematology, Biochemistry
Published
2022

5. GABA and its relationship to putrescine metabolism in the rat brain and pancreas

Author

Philip C. Caron, Lucien J. Cote, and Leon T. Kremzner

Subjects
medicine.medical_specialty, Monoamine oxidase, Catabolism, Central nervous system, Neuropeptide, Cell Biology, Biology, Cellular and Molecular Neuroscience, chemistry.chemical_compound, Monoamine neurotransmitter, medicine.anatomical_structure, Endocrinology, nervous system, chemistry, Internal medicine, medicine, Putrescine, Diamine oxidase, Neurotransmitter
Abstract

The possibility that GABA may have its origin in putrescine was investigated in the rat pancreas, relative to the brain. These studies show that radioactive putrescine is converted to GABA at a similar rate in both the pancreas and brain, but that putrescine accounts for only a small fraction of the GABA found in these organs. Inhibitors of diamine and monoamine oxidases do not significantly change the GABA level in the pancreas. In contrast to the brain, where putrescine is catabolized to GABA via monoamine oxidase, the primary catabolic pathway of putrescine to GABA in the pancreas is via diamine oxidase. In vivo studies show that AOAA inhibits GABA-T activity to the same degree in the pancreas as in the brain, elevating GABA levels more than 2-fold in 4 h. GABA is metabolized more rapidly in the brain than the pancreas. Turnover times of GABA in the pancreas and brain are 1.9 and 1.0 h, respectively. The slower turnover of GABA in the pancreas than in the brain may relate to a neuromodulatory role for GABA, similar to that for neuropeptides. Developmental studies in the postnatal pancreas suggest a role for GABA in the maturation of insulin secretion.

Published
1987

6. Putrescine, a source of γ-aminobutyric acid in the adrenal gland of the rat

Author

Philip C. Caron, Lucien J. Cote, and Leon T. Kremzner

Subjects
Male, medicine.medical_specialty, Monoamine oxidase, Glutamate decarboxylase, Biology, Guanidines, Biochemistry, gamma-Aminobutyric acid, GABA transaminase, chemistry.chemical_compound, Internal medicine, Adrenal Glands, Polyamines, Putrescine, medicine, Animals, Molecular Biology, gamma-Aminobutyric Acid, Glutamate Decarboxylase, Adrenal gland, Amine oxidase (copper-containing), Brain, Rats, Inbred Strains, Cell Biology, Rats, medicine.anatomical_structure, Endocrinology, Pargyline, nervous system, chemistry, Female, Amine Oxidase (Copper-Containing), Diamine oxidase, Research Article, medicine.drug
Abstract

Putrescine is the major source of gamma-aminobutyric acid (GABA) in the rat adrenal gland. Diamine oxidase, and not monoamine oxidase, is essential for GABA formation from putrescine in the adrenal gland. Aminoguanidine, a diamine oxidase inhibitor, decreases the GABA concentration in the adrenal gland by more than 70% after 4 h, and almost to zero in 24 h. Studies using [14C]putrescine confirm that [14C]GABA is the major metabolite of putrescine in the adrenal gland. Inhibition of GABA transaminase by amino-oxyacetic acid does not change the GABA concentration in the adrenal gland, as compared with the brain, where the GABA concentration rises. With aminoguanidine, the turnover time of GABA originating from putrescine in the adrenal gland is 5.6 h, reflecting a slower rate of GABA metabolism compared with the brain. Since GABA in the adrenal gland is almost exclusively derived from putrescine, the role of GABA may relate to the role of putrescine as a growth factor and regulator of cell metabolism.

Published
1988

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