1. The role of blood in early endometrial-peritoneal interactions in a syngeneic mouse model of endometriosis
- Author
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Minoru Irahara, Natsuyo Ugumori, Hiroyuki Furumoto, Akira Kuwahara, Toshiyuki Yasui, Hirokazu Uemura, Masaharu Kamada, Anna Tani, Masahiko Maegawa, Ayako Kobayashi, Toshiya Matsuzaki, Satoshi Yamamoto, and Yuka Kasai
- Subjects
Pathology ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Endometriosis ,Cell Biology ,medicine.disease ,Reproductive Medicine ,Murine model ,Fibrinolysis ,medicine ,Syngeneic transplantation ,Syngeneic mouse ,Original Article ,Stage (cooking) ,business - Abstract
The aim of this study was to clarify the role of blood in the early stage of development of endometriotic lesions by developing a syngeneic transplantation model using immunocompetent mice.Endometriotic lesions were induced in C57BL/6 mice by an intraperitoneal injection of endometrial fragments plus saline or endometrial fragments plus blood. Some endometrial fragments plus blood were injected with heparin, hirudin or tissue plasminogen activator (tPA). Endometriotic lesions on days 1, 3 and 5 were evaluated by gross and microscopic findings.The areas of endometriotic lesions in the blood group (6.4 ± 1.7 mmBlood accelerates the early stage of development of endometriotic lesions when endometrial fragments plus blood are injected. Blood property might be involved in early endometrial-peritoneal interactions.
- Published
- 2010