1. Prevalence and Clinical Consequences of Colistin Heteroresistance and Evolution into Full Resistance in Carbapenem-Resistant Acinetobacter baumannii
- Author
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Hadas Kon, Amichay Hameir, Amir Nutman, Elizabeth Temkin, Alona Keren Paz, Jonathan Lellouche, David Schwartz, David S. Weiss, Keith S. Kaye, George L. Daikos, Anna Skiada, Emanuele Durante-Mangoni, Yael Dishon Benattar, Dafna Yahav, Vered Daitch, Mariano Bernardo, Domenico Iossa, Lena E. Friberg, Ursula Theuretzbacher, Leonard Leibovici, Yaakov Dickstein, Dina Pollak, Sigal Mendelsohn, Mical Paul, Yehuda Carmeli, Roni Bitterman, Hiba Zayyad, Fidi Koppel, Yael Zak-Doron, Sergey Altunin, Nizar Andria, Ami Neuberger, Anat Stern, Neta Petersiel, Marina Raines, Amir Karban, Noa Eliakim-Raz, Oren Zusman, Michal Elbaz, Heyam Atamna, Tanya Babich, Amos Adler, Inbar Levi, Ioannis Pavleas, Anastasia Antoniadou, Antigoni Kotsaki, Roberto Andini, Giusi Cavezza, Lorenzo Bertolino, Giuseppe Giuffre, Roberto Giurazza, Giuseppe Ruocco, Maria Galdo, Patrizia Murino, Adriano Cristinziano, Antonio Corcione, Rosa Zampino, Johan Mouton, and Lena Friberg
- Subjects
Microbiology (medical) ,Infectious Diseases ,General Immunology and Microbiology ,Ecology ,Physiology ,Genetics ,Cell Biology - Abstract
To our knowledge, this is the first large-scale study to report on HR in Gram-negative bacteria. We described the prevalence of colistin HR in a large sample of carbapenem-resistant A. baumannii isolates, the evolution of many colistin HR isolates to a resistant phenotype following colistin exposure and withdrawal, and the clinical consequences of colistin HR.
- Published
- 2023