1. Guidelines and definitions for research on epithelial–mesenchymal transition
- Author
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Kyra Campbell, Ruby Yun-Ju Huang, Binhua P. Zhou, Yoshiko Takahashi, Yibin Kang, Cédric Blanpain, Antonio García de Herreros, Ben Z. Stanger, Amparo Cano, Gerhard Christofori, Jordi Casanova, Jean Paul Thiery, Jing Yang, Chaya Kalcheim, Geert Berx, Raghu Kalluri, Sendurai A. Mani, Marc P. Stemmler, Yeesim Khew-Goodall, Marianne E. Bronner, Thomas Brabletz, Heide L. Ford, Masatoshi Takeichi, Jonas Fuxe, Rik Derynck, Anna-Katerina Hadjantonakis, Shoukat Dedhar, Parker B. Antin, M. Angela Nieto, Donald F. Newgreen, Herbert Levine, Raymond B. Runyan, Guojun Sheng, Robert A. Weinberg, Gregory J. Goodall, Keith E. Mostov, Erik W. Thompson, Roberto Mayor, Eric Theveneau, Pierre Savagner, Alain Puisieux, Jinsong Liu, Joan Massagué, Elizabeth D. Williams, Gregory D. Longmore, Jianhua Xing, David R. McClay, Yang, Jing, Antin, Parker, Berx, Geert, Blanpain, Cédric, Goodall, Gregory J, Khew-Goodall, Yeesim, Sheng, Guojun, EMT International Association (TEMTIA), UAM. Departamento de Bioquímica, and Instituto de Investigaciones Biomédicas 'Alberto Sols' (IIBM)
- Subjects
Web of science ,cell migration ,Medicina ,Lung metastasis ,Diversity in experimental ,Regulació cel·lular -- Guies ,Definitions ,Guidelines ,Cellular organization ,Terminology ,EMBRYONIC HEART ,03 medical and health sciences ,0302 clinical medicine ,E-CADHERIN EXPRESSION ,Developmental biology ,Medicine and Health Sciences ,Epithelial–mesenchymal transition ,PLASTICITY ,epithelial–mesenchymal transition (EMT) ,Molecular Biology ,TRANSCRIPTION FACTOR SNAIL ,030304 developmental biology ,Research data ,FIBROBLAST-GROWTH-FACTOR ,Epithelial–mesenchymal transition (EMT) ,Cancer ,Cognitive science ,0303 health sciences ,Cèl·lules epitelials ,Nomenclature ,EMT ,Consensus Statement ,Biology and Life Sciences ,Biologie moléculaire ,Cell movement ,Cell Biology ,COLLAGEN GELS ,Epithelial-mesenchymal transition ,3. Good health ,Conceptual framework ,NEURAL CREST CELLS ,030220 oncology & carcinogenesis ,REPRESSES E-CADHERIN ,Consensus statement ,embryonic structures ,LUNG METASTASIS ,Biologie cellulaire ,Psychology - Abstract
On behalf of the EMT International Association (TEMTIA)., Epithelial–mesenchymal transition (EMT) encompasses dynamic changes in cellular organization from epithelial to mesenchymal phenotypes, which leads to functional changes in cell migration and invasion. EMT occurs in a diverse range of physiological and pathological conditions and is driven by a conserved set of inducing signals, transcriptional regulators and downstream effectors. With over 5,700 publications indexed by Web of Science in 2019 alone, research on EMT is expanding rapidly. This growing interest warrants the need for a consensus among researchers when referring to and undertaking research on EMT. This Consensus Statement, mediated by ‘the EMT International Association’ (TEMTIA), is the outcome of a 2-year-long discussion among EMT researchers and aims to both clarify the nomenclature and provide definitions and guidelines for EMT research in future publications. We trust that these guidelines will help to reduce misunderstanding and misinterpretation of research data generated in various experimental models and to promote cross-disciplinary collaboration to identify and address key open questions in this research field. While recognizing the importance of maintaining diversity in experimental approaches and conceptual frameworks, we emphasize that lasting contributions of EMT research to increasing our understanding of developmental processes and combatting cancer and other diseases depend on the adoption of a unified terminology to describe EMT.
- Published
- 2020