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Start Over Author "Kurz RW" Topic ceftriaxone
2 results on '"Kurz RW"'

1. Effect of cefotaxime, ceftriaxone and latamoxef on blood coagulation in patients on parenteral nutrition.

Author

Graninger W, Kurz RW, Havel MP, Horcher E, and Müller MM

Subjects
Aged, Clinical Trials as Topic, Drug Evaluation, Female, Gastrointestinal Diseases surgery, Humans, Male, Middle Aged, Parenteral Nutrition, Random Allocation, Blood Coagulation drug effects, Cefotaxime therapeutic use, Ceftriaxone therapeutic use, Gastrointestinal Diseases blood, Moxalactam therapeutic use
Abstract

Plasmatic coagulation parameters were studied in patients on parenteral cephalosporins with different hepatic pharmacokinetics. Sixty patients received either cefotaxime (4 g/day), ceftriaxone (2 g/day) or latamoxef (4 g/day) pre- and postoperatively for at least 5 days at random. They received parenteral nutrition without vitamin K supply and had no oral intake. A significant drop (p less than 0.05) in vitamin-K-dependent coagulation factors was recorded in patients treated with latamoxef, while patients receiving ceftriaxone and cefotaxime did not exhibit a significant change in their plasmatic coagulation parameters. Interference of some cephalosporins with the vitamin-K-dependent hepatic metabolism of clotting factors seems to be likely, rather than a suppression of intestinal vitamin K production by the intestinal microflora.

Published
1987
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2. Effect of cefotaxime, ceftriaxone and latamoxef on blood coagulation in patients on parenteral nutrition

Author

M.P. Havel, E. Horcher, M.M. Müller, Kurz Rw, and Wolfgang Graninger

Subjects
Male, Parenteral Nutrition, Cefotaxime, medicine.drug_class, Gastrointestinal Diseases, Cephalosporin, Antibiotics, chemistry.chemical_compound, Random Allocation, Pharmacokinetics, Drug Discovery, medicine, Humans, Pharmacology (medical), Blood Coagulation, Aged, Moxalactam, Pharmacology, Clotting factor, Clinical Trials as Topic, business.industry, Ceftriaxone, General Medicine, Middle Aged, Latamoxef, Infectious Diseases, Parenteral nutrition, Oncology, chemistry, Anesthesia, Drug Evaluation, Female, business, medicine.drug
Abstract

Plasmatic coagulation parameters were studied in patients on parenteral cephalosporins with different hepatic pharmacokinetics. Sixty patients received either cefotaxime (4 g/day), ceftriaxone (2 g/day) or latamoxef (4 g/day) pre- and postoperatively for at least 5 days at random. They received parenteral nutrition without vitamin K supply and had no oral intake. A significant drop (p less than 0.05) in vitamin-K-dependent coagulation factors was recorded in patients treated with latamoxef, while patients receiving ceftriaxone and cefotaxime did not exhibit a significant change in their plasmatic coagulation parameters. Interference of some cephalosporins with the vitamin-K-dependent hepatic metabolism of clotting factors seems to be likely, rather than a suppression of intestinal vitamin K production by the intestinal microflora.

Published
1987

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