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1. Cefodizime, an aminothiazolylcephalosporin. V. Synthesis and structure-activity relationships in the cefodizime series.

Author

Blumbach J, Dürckheimer W, Ehlers E, Fleischmann K, Klesel N, Limbert M, Mencke B, Reden J, Scheunemann KH, and Schrinner E

Subjects
Animals, Bacteria drug effects, Cefotaxime chemical synthesis, Cefotaxime metabolism, Cefotaxime pharmacology, Dogs, Half-Life, Indicators and Reagents, Kinetics, Mice, Microbial Sensitivity Tests, Structure-Activity Relationship, Cefotaxime analogs & derivatives
Abstract

The synthesis as well as in vitro antibacterial activity and pharmacokinetic behavior of cefodizime (HR 221, 1a), its analogs and derivatives is described. In this comparison, cefodizime stands out for its balance between its high antibacterial activity, prolonged elimination half-life and high AUC in mice and dogs.

Published
1987
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