1. Pharmacokinetics of Total and Unbound Cefazolin during Veno-Arterial Extracorporeal Membrane Oxygenation: A Case Report.
- Author
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Dhanani JA, Lipman J, Pincus J, Townsend S, Livermore A, Wallis SC, Abdul-Aziz MH, and Roberts JA
- Subjects
- Adult, Area Under Curve, Cefazolin blood, Cefazolin metabolism, Female, Half-Life, Heart Arrest complications, Heart Arrest diagnosis, Humans, Protein Binding, Pulmonary Embolism complications, Pulmonary Embolism pathology, ROC Curve, Cefazolin administration & dosage, Extracorporeal Membrane Oxygenation
- Abstract
Extra-corporeal membrane oxygenation (ECMO) therapy could affect effective drug concentrations via adsorption onto the oxygenator or associated circuit. We describe a case of a 25-year-old female who required a veno-arterial ECMO therapy for refractory cardiac arrest due to massive pulmonary embolism. She had mild renal dysfunction as a result of the cardiac arrest. A total of 2 g of intravenous cefazolin 8-hourly was administered. Pre- and post-oxygenator blood samples were collected at 0, 1, 4, and 8 h post antibiotic administration. Samples were analyzed for total and unbound cefazolin concentrations. Protein binding was ∼60%. Clearance was reduced due to impaired renal function. The pharmacokinetics of cefazolin appear to not be affected by ECMO therapy and dosing adjustment may not be required., (© 2019 S. Karger AG, Basel.)
- Published
- 2019
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