1. TCR-signals downstream adversely correlate with the survival signals of memory CD8 + T cells under homeostasis.
- Author
-
Yadav N, Patel H, Parmar R, Patidar M, and Dalai SK
- Subjects
- Mice, Animals, Lymphocyte Activation, Mice, Inbred C57BL, Antigens metabolism, Homeostasis, Mice, Transgenic, CD8-Positive T-Lymphocytes, Receptors, Antigen, T-Cell metabolism
- Abstract
The significance of self-peptide-MHC-I/TCR (SMT) interaction in the survival of CD8
+ T cells during naïve- and developmental-stages is well documented. However, the same for the memory stage is contentious. Previous studies have attempted to address the issue using MHC-I or TCR deficient systems, but inconsistent findings with memory CD8+ T cells of different TCR specificities have complicated the interpretation. Differential presence and/or processing of TCR-signals downstream in memory CD8+ T cells of different TCR specificities could be thought of as a reason. In this study, we examined the TCR-signals downstream in memory CD8+ T cells and compared them to the presence of survival-related signals (Annexin-V, Bcl-2, and Ki-67). We categorically tracked foreign antigen-experienced memory CD8+ T (TM) cells generated after Plasmodium pre-erythrocytic-stage malaria infection in C57BL/6 mice. Interestingly, we found that memory CD8+ T cells had more TCR-signals downstream than naive cells. We reasoned and attributed the increased expression of cell adhesion molecules to the enhanced TCR-signaling. TCR-signals downstream correlate more closely with survival signals in naive CD8+ T cells than with death signals in TM cells. Further investigation using antigen-specific CD8+ T cells and diverse infection systems would aid in conceptualizing the findings., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier GmbH. All rights reserved.)- Published
- 2023
- Full Text
- View/download PDF