1. Elevated Expression of CD160 and 2B4 Defines a Cytolytic HIV-Specific CD8+ T-Cell Population in Elite Controllers.
- Author
-
Pombo, Carolina, Wherry, E. John, Gostick, Emma, Price, David A., and Betts, Michael R.
- Subjects
- *
CD antigens , *CYTOTOXIC T cells , *HIV prevention , *GENE expression , *DISEASE progression , *COHORT analysis , *STATISTICAL correlation , *ANTIGENS , *CELL receptors , *CHRONIC diseases , *GLYCOPROTEINS , *HIV , *HIV infections , *RESEARCH funding , *RNA , *T cells , *GENETIC markers , *CYTOTOXINS , *MONONUCLEAR leukocytes - Abstract
During chronic human immunodeficiency virus (HIV) infection, virus-specific CD8(+) T cells become functionally exhausted. Unlike most chronically infected individuals, elite controllers of HIV retain CD8(+) T-cell polyfunctionality and cytolytic capacity. It remains unclear whether elite controllers manifest T-cell exhaustion similar to subjects with chronic progression of HIV infection. Here we assessed coexpression of PD-1, Lag-3, CD160, and 2B4 as a measure of T-cell exhaustion in a cohort of elite controllers and in chronic progressors. We found that elite controllers have a high proportion of potentially exhausted (PD1(+)CD160(+)2B4(+)) HIV-specific CD8(+) T cells that is comparable to the proportion in chronic progressors. However, elite controllers also harbor a population of HIV-specific CD160(+)2B4(+) CD8(+) T cells that correlates with cytolytic capacity, as measured by perforin expression, a population not commonly present in chronic progressors. We therefore propose that coexpression of CD160 and 2B4 delineates a population of cytolytic CD8(+) T cells important for the control of HIV. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF