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Interactive erosion and cavitation wear widely exist in engineering. Based on the principle of orthogonal experiment, flow pressure, erosion angle, and rotational speed are selected for the interactive erosion and cavitation wear experiment on plastic material 40Cr, 45 steel, and brittle material HT200 using the L9 (3x4) orthogonal experiment table. The wear loss and the SEM (scanning electron microscope) photo of the specimen are also analysed. The result shows that the main factors that influence interactive erosion and cavitation wear loss are flow pressure, erosion angle, and rotational speed from primary to secondary. For 40Cr and 45 steel, the difference in the R value between the three factors is small. For HT200, the R value of pressure on interactive wear is the highest, which is signifi- cantly different from the R value of rotational speed. Under the same rotational speed, erosion angle, flow pressure, and other environmental factors, cavitation caused by pressure is the major wear form for brittle materials with smaller elongation. The impact strength of micro-bubble collapse can easily reach its fatigue strength. Materials peel off in patches under repeated impacts of micro-bubble collapse and sand grains, which aggravates the degree of interactive wear. The anti-cavitation capacity of the plastic materials with large elongation is strong, with erosion wear, to a lesser degree. [ABSTRACT FROM AUTHOR]