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Background Ovarian cancer has been named the silent killer because it frequently causes non specific symptoms which contribute to diagnostic delay diagnosis in a late stage and poor prognosis Despite of the improved surgical techniques and effective chemotherapeutic regimens available for management of ovarian cancer there is no improvement in its early detection Thus ovarian cancer remains a leading cause of death from gynecological malignancies with an overall poor prognosis The identification of novel cancer biomarker opens the possibility for early detection better monitoring of tumor progression Haptoglobin is a novel biomarker which was used in diagnosis in ovarian cancer Objectives To assess the performance of haptoglobin and CA to increase the sensitivity and specificity in diagnosis of nature of ovarian mass and to assess the diagnostic value of haptoglobin in cases of ovarian neoplasia Methods This study was carried out on women attending El Hussein and Bab El Sheria University Hospital a prospective study was held on patients with ovarian mass prepared for surgery It is a case control study It incorporated on patients with ovarian masses and women without masses Those patients were subjected to careful history taking clinical examination ultrasound examination and preoperative assessment of serum levels of Haptoglobin and CA