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Start Over Author "Bhunia, Anil K." Topic cations
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1. Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents.

Author

Hanaoka, Kazushige, Qian, Feng, Boletta, Alessandra, Bhunia, Anil K., Piontek, Klaus, Tsiokas, Leonidas, Sukhatme, Vikas P., Guggino, William B., and Germino, Gregory G.

Subjects
KIDNEY tubules, CATIONS, POLYCYSTIC kidney disease, PROTEINS
Abstract

Shows that polycystin-1 and -2 interact to produce new calcium-permeable non-selective cation currents. Localization of polycystin-2 in the cell in the absence of polycystin-1 and its translocation to the plasma membrane in its presence; Role of these proteins in the regulation of renal tubular morphology and function; Implications for autosomal dominant polycystic kidney disease.

Published
2000
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