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Objective To investigate the effect of extrahospital continuous nursing with indwelling peripherally inserted central catheter（PICC）in the patients with abdominal and pelvic tumor. Methods A total of 328 patients with abdominal and pelvic tumor and extrahospital continuous nursing with indwelling PICC in the department of abdominal tumor of the Affiliated Hospital of Zunyi Medical College from June 2014 to June 2017 were selected as the research subjects and divided into the con- trol group（69 cases）and intervention group（259 cases）. The control group implemented the general health knowledge educa- tion and nursing care，and on this basis the intervention group implemented the continuous nursing mode such as the medical treatment alliance，assist，WeChat platform，grading telephone follow up，etc. The contents included the catheter complications， self management ability，health promoting lifestyle，nursing satisfaction. The follow up lasted for 6 months. Results The incidence rate of catheter complications in the intervention group was 4.6%（12/259），which was significantly lower than 21.7% （15/69）in the control group, the difference was statistically significant（X2=2.25，P=0.002）. The total average scores of catheter self-management ability and dimensional scores of everyday catheter observation，maintenance compliance, catheter management confidence，treatment of abnormal condition，information obtaining and daily living with indwelling PICC in the intervention group were higher than those in the control group，while the maintenance compliance score was lower than that in the control group，the differences were statistically significant（P<0.05）. In the health promoting lifestyle mode，the differences were statistically significant（P<0.05）. The nursing satisfaction in the intervention group was（97.90±1.13）%，which was sig- nificantly higher than（93.28±1.51）% in the control group，the difference was statistically significant（t=-15.082，P=0.000）. Conclusion Carrying out the multiform follow up in the patients with abdominal and pelvic tumor and discharge with indwell- ing PICC can improve the self-management ability on catheter and health knowledge level，reduces the catheter-related compli- cations and ensures the safety of catheter use. [ABSTRACT FROM AUTHOR]