1. [Study of serum kinetics of vancomycin during the "antibiotic-lock" technique].
- Author
-
Elian JC, Frappaz D, Ros A, Gay JP, Guichard D, Dorche G, Aubert G, Bouteille M, Ollagnier M, and Freycon F
- Subjects
- Adolescent, Bacteremia drug therapy, Bacteremia etiology, Child, Preschool, Humans, Staphylococcal Infections drug therapy, Staphylococcal Infections etiology, Staphylococcus epidermidis, Surgical Wound Infection drug therapy, Surgical Wound Infection etiology, Vancomycin administration & dosage, Vancomycin blood, Vancomycin therapeutic use, Catheterization, Central Venous adverse effects, Vancomycin pharmacokinetics
- Abstract
The serum kinetics of vancomycin was studied in two patients aged 3 and 15 years during antibiotic therapy for catheter related sepsis associated with Staphylococcus epidermidis. Vancomycin was administered, simultaneously, by parenteral conventional doses (30 mg/kg/day div q 8 h) and using the antibiotic-lock technique in the infected catheter at a high concentration (150 mg/ml) during one hour, 3 hours after each infusion. Pharmacokinetics data did not show any significant change in the serum kinetics of the antibiotic. The results suggest that delivering a high concentration of vancomycin in the infected catheter using the lock technique may be useful to sterilize infected catheter without toxic effect.
- Published
- 1992