1. New method for the synthesis of thieno[2,3-d]pyrimidines.
- Author
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Ryabova, O.B., Evstratova, M.I., Makarov, V.A., Tafeenko, V.A., and Granik, V.G.
- Subjects
PYRIMIDINES ,NITROMETHANE ,RING formation (Chemistry) ,THIOPHENES ,CATALYSTS ,CRYSTALLOGRAPHY ,CHEMICAL structure - Abstract
The reaction of 5-formyl-4-thiocyanatopyrimidines with nitromethane was studied under various conditions. The reaction was found unexpectedly to proceed with closure of a thiophene ring to give thieno[2,3-d]pyrimidines. The use of ammonium acetate as the catalyst leads to a side reaction involving closure of an isothiazole ring to give isothiazolo[5,4-d]pyrimidines. X-ray diffraction crystallographic analysis was used to confirm the structure of thieno[2,3-d]pyrimidine. [ABSTRACT FROM AUTHOR]
- Published
- 2004
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