1. Photoredox-Catalyzed Dehydrogenative Csp3-Csp2 Cross-Coupling of Alkylarenes to Aldehydes in Flow
- Author
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Griffiths, Oliver M, Esteves, Henrique A, Chen, Yiding, Sowa, Karin, May, Oliver S, Morse, Peter, Blakemore, David C, Ley, Steven V, Griffiths, Oliver M [0000-0003-3954-9343], and Apollo - University of Cambridge Repository
- Subjects
Physical Phenomena ,Aldehydes ,Reproducibility of Results ,Catalysis - Abstract
Executing photoredox reactions in flow offers solutions to frequently encountered issues regarding reproducibility, reaction time, and scale-up. Here, we report the transfer of a photoredox-catalyzed benzylic coupling of alkylarenes to aldehydes to a flow chemistry setting leading to improvements in terms of higher concentration, shorter residence times, better yields, ease of catalyst preparation, and enhanced substrate scope. Its applicability has been demonstrated by a multi-gram-scale reaction using high-power light-emitting diodes (LEDs), late-stage functionalization of selected active pharmaceutical ingredients (APIs), and also a photocatalyst recycling method.
- Published
- 2021