150 results on '"Liu, Yan"'
Search Results
2. De novo construction of amine-functionalized metal-organic cages as heterogenous catalysts for microflow catalysis.
- Author
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Li, Yingguo, He, Jialun, Lu, Guilong, Wang, Chensheng, Fu, Mengmeng, Deng, Juan, Yang, Fu, Jiang, Danfeng, Chen, Xiao, Yu, Ziyi, Liu, Yan, Yu, Chao, and Cui, Yong
- Subjects
COVALENT bonds ,CHEMICAL synthesis ,MASS transfer ,WASTE recycling ,CATALYSIS - Abstract
Microflow catalysis is a cutting-edge approach to advancing chemical synthesis and manufacturing, but the challenge lies in developing efficient and stable multiphase catalysts. Here we showcase incorporating amine-containing metal-organic cages into automated microfluidic reactors through covalent bonds, enabling highly continuous flow catalysis. Two Fe
4 L4 tetrahedral cages bearing four uncoordinated amines were designed and synthesized. Post-synthetic modifications of the amine groups with 3-isocyanatopropyltriethoxysilane, introducing silane chains immobilized on the inner walls of the microfluidic reactor. The immobilized cages prove highly efficient for the reaction of anthranilamide with aldehydes, showing superior reactivity and recyclability relative to free cages. This superiority arises from the large cavity, facilitating substrate accommodation and conversion, a high mass transfer rate and stable covalent bonds between cage and microreactor. This study exemplifies the synergy of cages with microreactor technology, highlighting the benefits of heterogenous cages and the potential for future automated synthesis processes Microflow catalysis represents a cutting-edge method for advancing chemical synthesis and manufacturing, though developing efficient and stable multiphase catalysts remains challenging. Here the authors demonstrate the incorporation of amine-containing metal-organic cages into automated microfluidic reactors through covalent bonds, facilitating highly continuous flow catalysis. [ABSTRACT FROM AUTHOR]- Published
- 2024
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- View/download PDF
3. Cross‐Coupling Reaction of Alkyl Halides with Aldehydes through NHC Catalysis.
- Author
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Zhang, Zhuo‐Zhuo, Zeng, Rong, Liu, Yan‐Qing, and Li, Jun‐Long
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HALOALKANES ,RADICALS (Chemistry) ,ORGANOCATALYSIS ,CATALYSIS ,ALDEHYDES - Abstract
During the past decades, N‐heterocyclic carbene (NHC)‐catalyzed reactions have emerged as a versatile tool in synthetic chemistry. In particular, NHC‐catalyzed cross‐coupling reaction has been significantly developed in many respects, including new reaction development and mechanistic investigation. This concept article presents recent advances towards direct cross‐coupling reactions of aldehydes with alkyl halides enabled by NHC organocatalysis. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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4. Supramolecular Assembly Frameworks (SAFs): Shaping the Future of Functional Materials.
- Author
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Tang, Xianhui, Pang, Jiandong, Dong, Jinqiao, Liu, Yan, Bu, Xian‐He, and Cui, Yong
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POROUS materials ,COVALENT bonds ,SCIENTIFIC community ,POROSITY ,CATALYSIS - Abstract
Supramolecular assembly frameworks (SAFs) represent a new category of porous materials, utilizing non‐covalent interactions, setting them apart from metal–organic frameworks (MOFs) and covalent organic frameworks (COFs). This category includes but is not restricted to hydrogen‐bonded organic frameworks and supramolecular organic frameworks. SAFs stand out for their outstanding porosity, crystallinity, and stability, alongside unique dissolution‐recrystallization dynamics that enable significant structural and functional modifications. Crucially, their non‐covalent assembly strategies allow for a balanced manipulation of porosity, symmetry, crystallinity, and dimensions, facilitating the creation of advanced crystalline porous materials unattainable through conventional covalent or coordination bond synthesis. Despite their considerable promise in overcoming several limitations inherent to MOFs and COFs, particularly in terms of solution‐processability, SAFs have received relatively little attention in recent literature. This Minireview aims to shed light on standout SAFs, exploring their design principles, synthesis strategies, and characterization methods. It emphasizes their distinctive features and the broad spectrum of potential applications across various domains, aiming to catalyze further development and practical application within the scientific community. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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5. A Triode-like Enzyme-free Catalytic Circuit with Junction Fuel
- Author
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Luo, Tao, Wang, Xiaojing, Fan, Sisi, Liu, Yan, Cheng, Jin, Tang, Linlin, and Song, Jie
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- 2020
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6. Efficient production of α-ketoglutaric acid using an economical double-strain cultivation and catalysis system.
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Liu, Kun, Liu, Yan, Li, Xiangfei, Zhang, Xiushan, Xue, Zhenglian, and Zhao, Ming
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CATALYSIS , *ESCHERICHIA coli , *GLUTAMIC acid , *INDUSTRIAL capacity , *TITERS , *CHEMICAL synthesis - Abstract
The whole-cell catalysis strategy of alpha-ketoglutaric acid (α-KG) production from L-glutamic acid (L-Glu) using recombinant Escherichia coli, in which L-glutamate oxidase (LGox) was over-expressed, has replaced the traditional chemical synthesis strategy. However, large amounts of toxic by-product, H2O2, should be eliminated through co-expressing catalase (Cat), thus severely increasing burden in cells. To efficiently and economically produce α-KG, here, the genes SpLGox (from Streptomyces platensis NTU3304) and SlCat (from Streptomyces lividans TK24) were inserted into the low-dosage-IPTG (Isopropyl β-D-Thiogalactoside) inducible expression system, constructed in our previous work, in E. coli, respectively. Besides, a double-strain catalysis system was established and optimized to produce α-KG, and the productivity of α-KG was increased 97% compared with that through single strain catalysis. Finally, a double-strain cultivation strategy was designed and employed to simplify the scale-up fermentation. Using the optimized whole-cell biocatalyst conditions (pH 7.0, 35 °C), majority of the L-glutamic acid was transformed into α-KG and the titer reached 95.4 g/L after 6 h with the highest productivity at present. Therefore, this strategy may efficiently and cost-effectively produce α-KG, enhancing its potential for industrial applications. Key points: • SpLGox and SlCat were over-expressed to catalyze L-Glu to α-KG and eliminate by-product H2O2, respectively. • Double-strain cultivation and catalysis system can efficiently and cost-effectively produce α-KG from L-Glu. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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7. A positron emission tomography imaging probe selectively targeting the BD1 bromodomain and extra-terminal domain
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Ping Bai, Liu Yan, Frederick A. Bagdasarian, Moses Q. Wilks, Hsiao-Ying Wey, and Changning Wang
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Metals and Alloys ,Nuclear Proteins ,Cell Cycle Proteins ,General Chemistry ,Article ,Catalysis ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,Mice ,Protein Domains ,Positron-Emission Tomography ,Materials Chemistry ,Ceramics and Composites ,Animals ,Transcription Factors - Abstract
The two tandem bromodomains of BET (bromodomain and extra-terminal domain) proteins (BD1 and BD2) may play distinct and critical roles in neurological diseases. To better understand the underlying mechanisms of the BD1 bromodomain and facilitate brain permeable domain-selective inhibitor development, we describe here the development of the first BET BD1 positron emission tomography (PET) radioligand [(11)C]1a. Compound 1a was tested to possess potent binding affinities and good selectivity (>20-fold over BD2) for BD1 bromodomains of BRD2 (K(d) = 25 nM), BRD3 (K(d) = 24 nM), and BRD4 (K(d) = 19 nM). Physicochemical characterization of 1a indicated the brain permeability and specific binding. [(11)C]1a was radiosynthesized in a good radiochemical yield (RCY: 25–30%) and molar activity (258 GBq μmol(−1)). The PET imaging studies of [(11)C]1a in mice showed moderate brain uptake (with peak SUV = 0.7) and binding specificity. Furthermore, [(11)C]1a demonstrated translational potential in the non-human primate (NHP) PET imaging study, which sets the stage for clinical translation.
- Published
- 2022
8. Designing a Hierarchical Porous Carbon with Optimized Nitrogen Doping for Efficient Oxygen Reduction Reaction.
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Peng, Xingkai, Zhao, Xiaowei, Hu, Yuekun, Guo, Lingli, Liu, Yan, Yu, Xiaofei, Yang, Xiaojing, Zhang, Xinghua, Lu, Zunming, and Li, Lanlan
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OXYGEN reduction ,NITROGEN ,ZINC acetate ,AMINO group ,POWER density ,CARBON ,DOPING agents (Chemistry) - Abstract
Nitrogen‐doped carbon is considered one of the most promising oxygen reduction catalysts due to its low cost and high activity, however, it still falls short of Pt/C. In this study, we report a strategy for the preparation of highly reactive N‐doped hierarchical porous carbon by primary pyrolysis using zinc acetate as a stand‐alone zinc source and amino‐rich reactants as carbon and nitrogen sources to introduce Zn‐Nx structures into mesoporous structures generated by the hard template method using the strong coordination of zinc and amino groups. Benefited from the simultaneous optimization of the hierarchical porous structure and nitrogen‐doping, the half‐wave potential of Zn(OAc)2–DCD/HPC is as high as 0.909 V vs. RHE, much better than that of commercial Pt/C catalysts (0.872 V vs. RHE). In addition, zinc‐air batteries assembled with Zn(OAc)2–DCD/HPC (Pmax=198 mW cm−2) as the cathode exhibit higher peak power density compared to Pt/C (Pmax=168 mW cm−2). This strategy might open up new opportunities for designing and developing highly active metal‐free catalysts. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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9. Sr x Ti 1–x CoO 3± δ Perovskite‐like Catalysts with Enhanced Activity for Hydrogen Production
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Jia Huang, Huigu Li, Lihong Huang, Liu Yan, Zhang Yu, and Xiaomin Hu
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Acetic acid ,chemistry.chemical_compound ,Materials science ,chemistry ,Methane reformer ,Chemical engineering ,General Chemical Engineering ,General Chemistry ,Industrial and Manufacturing Engineering ,Hydrogen production ,Catalysis ,Perovskite (structure) - Published
- 2021
10. Nickel‐Catalyzed Unsymmetrical Bis‐Allylation of Alkynes.
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Li, Ying, Zhang, Wei‐Song, Yang, Sa‐Na, Wang, Xiao‐Yu, Liu, Yan, Ji, Ding‐Wei, and Chen, Qing‐An
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ALKYNES ,ALKENES ,TRIENES ,FUNCTIONAL groups ,ALLYLIC amination ,CATALYSIS - Abstract
The catalytic bis‐allylation of alkynes is an important but challenging protocol to construct all‐carbon tetra‐substituted alkenes. Particularly, the catalytic unsymmetrical bis‐allylation of alkynes remains as an underexplored task to date. We herein report an unprecedented unsymmetrical bis‐allylation by simultaneously utilizing electrophilic trifluoromethyl alkene and nucleophilic allylboronate as the allylic reagents. With the aid of robust Ni0/NHC catalysis, valuable skipped trienes can be obtained in high regio‐ and stereo‐selectivities under mild conditions. Mechanistic studies indicate that the reaction may proceed through a β‐fluorine elimination of a nickelacycle followed by a transmetalation step with allylboronate. The present method exhibits a good tolerance of various functional groups. Besides, the skipped triene products can undergo an array of elaborate transformations, which highlights the potential applications of this strategy. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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11. Transcriptome and Gene Co-Expression Network Analysis Identifying Differentially Expressed Genes and Signal Pathways Involved in the Height Development of Banana (Musa spp.)
- Author
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Bingyu Cai, Yixian Xie, Yufeng Chen, Miaomiao Cao, Junting Feng, Yuqi Li, Liu Yan, Yongzan Wei, Yankun Zhao, Jianghui Xie, and Wei Wang
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Inorganic Chemistry ,banana ,Organic Chemistry ,gene expression ,General Medicine ,Physical and Theoretical Chemistry ,transcriptome ,Molecular Biology ,gibberellic acid ,Spectroscopy ,Catalysis ,plant height ,Computer Science Applications - Abstract
Plant height is an important and valuable agronomic trait associated with yield and resistance to abiotic and biotic stresses. Dwarfism has positive effects on plant development and field management, especially for tall monocotyledon banana (Musa spp.). However, several key genes and their regulation mechanism of controlling plant height during banana development are unclear. In the present study, the popular cultivar ‘Brazilian banana’ (‘BX’) and its dwarf mutant (‘RK’) were selected to identify plant height-related genes by comparing the phenotypic and transcriptomic data. Banana seedlings with 3–4 leaves were planted in the greenhouse and field. We found that the third and fourth weeks are the key period of plant height development of the selected cultivars. A total of 4563 and 10507 differentially expressed genes (DEGs) were identified in the third and fourth weeks, respectively. Twenty modules were produced by the weighted gene co-expression network analysis (WGCNA). Eight modules were positively correlated with the plant height, and twelve other modules were negatively correlated. Combining with the analysis of DEGs and WGCNA, 13 genes in the signaling pathway of gibberellic acid (GA) and 7 genes in the signaling pathway of indole acetic acid (IAA) were identified. Hub genes related to plant height development were obtained in light of the significantly different expression levels (|log2FC| ≥ 1) at the critical stages. Moreover, GA3 treatment significantly induced the transcription expressions of the selected candidate genes, suggesting that GA signaling could play a key role in plant height development of banana. It provides an important gene resource for the regulation mechanism of banana plant development and assisted breeding of ideal plant architecture.
- Published
- 2023
12. Catalytic Dimerization of Bio-Based 5-methylfurfuryl Alcohol to Bis(5-methylfuran-2-yl) Methane with a Solid Acidic Nanohybrid
- Author
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Hu Li, Liu Yan, Yuanzhong Li, Chengjiang Fang, Song Yang, Duo Jin, and Shi Yuanhui
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010405 organic chemistry ,Chemistry ,020209 energy ,Biomedical Engineering ,Pharmaceutical Science ,Medicine (miscellaneous) ,Bio based ,Bioengineering ,Methylfurfuryl alcohol ,02 engineering and technology ,01 natural sciences ,Methane ,0104 chemical sciences ,Catalysis ,chemistry.chemical_compound ,0202 electrical engineering, electronic engineering, information engineering ,Organic chemistry ,Biotechnology - Abstract
Background:: Liquid C8-C15 long-chain alkanes, as the main components of jet fuels or diesel, can be synthetized from abundant and renewable biomass derivatives by extending the carbon- chain length through cascade C-C coupling over acidic catalysts and hydrodeoxygenation over metal particles. Objective:: This research aims to develop a carbon-increasing catalytic process through the dimerization of 5-methylfurfuryl alcohol to produce the C11 oxygenate bis(5-methylfuran-2-yl) methane. Method:: In this work, 5-methylfurfural, derivable from sugars, could be reduced to the expensive 5- methylfurfuryl alcohol over Cs2CO3 using an eco-friendly hydride polymethylhydrosiloxane. In the subsequent carbon-increasing process, a solid acidic nanocatalyst 3-chlorpyridine phosphotungstic acid (3-ClPYPW) was developed to be efficient for the conversion of 5-methylfurfuryl alcohol to bis(5-methylfuran-2-yl) methane under mild reaction conditions. Results:: A good bis(5-methylfuran-2-yl) methane yield of 51.6% was obtained using dichloromethane as a solvent at a low temperature of 70°C in 11 h. The solid nanocatalyst was able to be reused for at least four cycles without a remarkable loss of catalytic activity. The kinetic study proved that the reaction is a first-order reaction with apparent activation energy (Ea) of 41.10 kJ mol-1, while the thermodynamic study certified that the reaction is non-spontaneous and endothermic. Conclusion:: A novel catalytic pathway for the synthesis of BMFM (C11 oxygenate) by the one-pot process was successfully developed over solid acidic nanocatalysts 3-ClPYPW.
- Published
- 2020
13. Oxidative Radical NHC Catalysis: Divergent Difunctionalization of Olefins through Intermolecular Hydrogen Atom Transfer.
- Author
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Li, Qing‐Zhu, Liu, Yan‐Qing, Kou, Xin‐Xin, Zou, Wen‐Lin, Qi, Ting, Xiang, Peng, Xing, Jin‐Dun, Zhang, Xiang, and Li, Jun‐Long
- Subjects
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ORGANOCATALYSIS , *PHASE-transfer catalysis , *CHEMICAL amplification , *ABSTRACTION reactions , *CATALYSIS , *REACTIVE oxygen species , *ALKENES - Abstract
Oxidative N‐heterocyclic carbene (NHC) organocatalysis, typically leading to the formation of acyl azolium reactive intermediates, constitutes one of the most important activation strategies for the NHC‐catalyzed chemical transformations. Here, we report an unprecedented oxidative radical NHC catalysis by using peroxyester as the external single‐electron oxidant to realize divergent difunctionalization of olefins. The key to success of this chemistry is the catalytic generation of oxygen radicals that could trigger an intermolecular hydrogen atom transfer to activate the inert C−H bonds, thereby enabling the productive radical relay process. With this protocol, commonly used general chemicals could serve as radical precursors to allow efficient synthesis of value‐added products in a straightforward and cost‐effective manner. Preliminary mechanistic investigations, including control experiments and DFT calculations, shed light on the NHC organocatalytic radical reaction mechanism. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
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14. In situ Deposition of ‘Naked’ Gold Nanoparticles Supported on Silica Spheres as Recyclable Catalysts in Styrene Epoxidation
- Author
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Xinyu Zhou, Li Miao, Liu Yan, Qihui Shen, and Yang Lyu
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Materials science ,Nanoparticle ,02 engineering and technology ,General Chemistry ,engineering.material ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,Catalysis ,Styrene ,Solvent ,chemistry.chemical_compound ,chemistry ,Chemical engineering ,Colloidal gold ,Styrene oxide ,engineering ,Noble metal ,0210 nano-technology ,Selectivity - Abstract
The rational designs of particle size, morphology and surface states of the Au nanoparticles(AuNPs) are crucial for Au nanocatalyst. We herein report a method to synthesize the silica microspheres supported AuNPs(ca. 1 nm) and their application in controlling the reaction conversion and selectivity in styrene epoxidation. Surfactant-free AuNPs deposited on silica microspheres were in situ fabricated with aid of the Ag nanoparticles (AgNPs) as sacrificial template by galvanic replacement reaction, leading to AuNPs/SiO2 catalyst directly without any post-treatment to expose crystal facets. A high conversion of 46.7% and selectivity of 91.7% to styrene oxide was achieved with H2O2 as oxidant in ethanol. The solid catalyst could be reused at least 10 reaction cycles without significant decrease in activity and selectivity. This study not only supplies an active, recoverable catalyst for styrene oxidation with green oxidant and solvent, but also demonstrates that the silica microspheres functionalized with thiol groups have a superior ability in stabilizing noble metal nanoparticles even without any surfactant.
- Published
- 2019
15. Synthesis and Characterization of Iron-Substituted ZSM-23 Zeolite Catalysts with Highly Selective Hydroisomerization of n-Hexadecane
- Author
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Xiao Chen, Liu Yan, Chuang Li, Changhai Liang, Chi-Wing Tsang, and Yujing Chen
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Materials science ,Infrared ,General Chemical Engineering ,02 engineering and technology ,General Chemistry ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Highly selective ,01 natural sciences ,Industrial and Manufacturing Engineering ,0104 chemical sciences ,Catalysis ,Characterization (materials science) ,symbols.namesake ,Fourier transform ,N-hexadecane ,symbols ,0210 nano-technology ,Zeolite ,Nuclear chemistry - Abstract
A series of Fe-substituted ZSM-23 samples with different Fe/(Fe + Al) ratios were synthesized. Combined characterization by Fourier transform infrared spectroscopic, ESR, and X-ray photoelectron sp...
- Published
- 2018
16. Dry Reforming of Shale Gas and Carbon Dioxide with Ni-Ce-Al2O3Catalyst: Syngas Production Enhanced over Ni-CeOxFormation
- Author
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Liu Yan, Zarina Akhtamberdinova, Guodong Jiang, Xiaoping Chen, Ye Wu, and Dong Liu
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Materials science ,Carbon dioxide reforming ,Shale gas ,Organic Chemistry ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Catalysis ,0104 chemical sciences ,Inorganic Chemistry ,chemistry.chemical_compound ,Chemical engineering ,chemistry ,Carbon dioxide ,Physical and Theoretical Chemistry ,0210 nano-technology ,Syngas - Published
- 2018
17. Synthesis of ZSM-23 zeolite with dual structure directing agents for hydroisomerization of n-hexadecane
- Author
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Liu Yan, Chuang Li, Xiao Chen, Changhai Liang, and Yujing Chen
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02 engineering and technology ,General Chemistry ,Microporous material ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,01 natural sciences ,Pyrrolidine ,0104 chemical sciences ,Catalysis ,law.invention ,chemistry.chemical_compound ,chemistry ,Mechanics of Materials ,law ,Polymer chemistry ,General Materials Science ,Isopropylamine ,Crystallization ,0210 nano-technology ,Zeolite ,Selectivity ,Bifunctional - Abstract
Highly crystallized ZSM-23 zeolite samples were synthesized by employing the dual structure directing agents pyrrolidine (PY) and isopropylamine (IPA). The existence of two types of structure directing agents widened the synthesis composition ratio range and speeded up the crystallization. The samples obtained showed larger micropore surface areas and volumes compared with the products synthesized with single SDA. It was found that the use of the dual-structure directing agent had no effect on the total acidity but altered the acid site distribution where more weak and medium acidic sites were exposed and was found to be more suitable for n-hexadecane hydroisomerization. The bifunctional catalysts prepared from the supports using the dual-structure directing agent showed excellent catalytic performance under certain reaction conditions. It was noteworthy that Pt/PI-200 (Pt supported on the dual-structure directing agent with a SiO2/Al2O3 ratio of 200) showed a constant selectivity to iso-hexadecane ca. 69% with contact time of 0.75 min and longer.
- Published
- 2018
18. Studies on the Stability of a La0.8Pr0.2NiAl11O19 Catalyst for Syngas Production by CO2 Reforming of Methane
- Author
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Liu, Yan, Cheng, Tiexin, Li, Dongmei, Jiang, Pengbo, Wang, Junxia, Li, Wenxing, Bi, Yingli, and Zhen, Kaiji
- Published
- 2003
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19. Synergistic oxidation of Bisphenol A in a heterogeneous ultrasound-enhanced sludge biochar catalyst/persulfate process: Reactivity and mechanism
- Author
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Fu Xin Dong, Zeng Hui Diao, Zhi Liang Chen, Liu Yan, Xue Qin Tao, Dan Jiang, Ling Jun Kong, Tao Zhang, Wei Chu, Wei Qian, Zai Wang Zhang, and Jian Jun Du
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Bisphenol A ,Environmental Engineering ,Health, Toxicology and Mutagenesis ,0211 other engineering and technologies ,02 engineering and technology ,010501 environmental sciences ,Wastewater ,01 natural sciences ,Catalysis ,Sonochemistry ,Water Purification ,Hydroxylation ,chemistry.chemical_compound ,Phenols ,Biochar ,Environmental Chemistry ,Humic acid ,Benzhydryl Compounds ,Waste Management and Disposal ,0105 earth and related environmental sciences ,Demethylation ,chemistry.chemical_classification ,021110 strategic, defence & security studies ,Sewage ,Sulfates ,Persulfate ,Pollution ,Sodium Compounds ,chemistry ,Ultrasonic Waves ,Charcoal ,Oxidation-Reduction ,Water Pollutants, Chemical ,Nuclear chemistry - Abstract
Recently, clean-up of resistant organic compounds has attracted growing attention. In this study, a novel heterogeneous ultrasound-enhanced sludge biochar catalyst/persulfate (BC/PS/US) process was firstly developed for the degradation of bisphenol A (BPA) in water. The results revealed that BC/PS/US process could successfully achieve a positively synergistic effect between sonochemistry and catalytic chemistry on the degradation of BPA compared to its corresponding comparative process. Nearly 98% of BPA could be degraded within 80 min at optimum reaction conditions. The coexisting substances including Cl−, SO42- and NO3− had no obvious inhibition on the BPA degradation, whereas HCO3− and humic acid (HA) had significant inhibition effects on that. PS decomposition of BC/PS/US process was superior to that of BC/PS or US/PS process. Both SO4 ― and HO participated in the degradation of BPA, but SO4 ― was predominant radical in the BC/PS/US process. A possible pathway of BPA degradation was proposed, and the BPA molecule was attacked by SO4 ― and degraded into five kinds of intermediate products through hydroxylation and demethylation processes. This study helps to comprehend the application of sludge biochar catalyst as a persulfate activator for the degradation of organic compounds under ultrasound irradiation, and provides a new strategy in wastewater treatment.
- Published
- 2019
20. Ectopic Expression of Poplar ABC Transporter PtoABCG36 Confers Cd Tolerance in Arabidopsis thaliana
- Author
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Yuanyuan Liu, Liping Sun, Jianchun Li, Zaihui Peng, Huihong Wang, Wang Xuening, Erqin Han, Nengbiao Wu, Keming Luo, Shengli Xie, Bangjun Wang, Liu Yan, and Weipeng Huang
- Subjects
0106 biological sciences ,0301 basic medicine ,Transgene ,chemistry.chemical_element ,ATP-binding cassette transporter ,01 natural sciences ,Catalysis ,Cd ,Inorganic Chemistry ,lcsh:Chemistry ,03 medical and health sciences ,Arabidopsis ,PtoABCG36 ,Arabidopsis thaliana ,Physical and Theoretical Chemistry ,Molecular Biology ,lcsh:QH301-705.5 ,Spectroscopy ,Cadmium ,tolerance ,biology ,Organic Chemistry ,fungi ,Transporter ,General Medicine ,biology.organism_classification ,efflux ,Computer Science Applications ,Cell biology ,030104 developmental biology ,chemistry ,lcsh:Biology (General) ,lcsh:QD1-999 ,poplar ,Ectopic expression ,Efflux ,accumulation ,010606 plant biology & botany - Abstract
Cadmium (Cd) is one of the most toxic heavy metals for plant growth in soil. ATP-binding cassette (ABC) transporters play important roles in biotic and abiotic stresses. However, few ABC transporters have been characterized in poplar. In this study, we isolated an ABC transporter gene PtoABCG36 from Populus tomentosa. The PtoABCG36 transcript can be detected in leaves, stems and roots, and the expression in the root was 3.8 and 2 times that in stems and leaves, respectively. The PtoABCG36 expression was induced and peaked at 12 h after exposure to Cd stress. Transient expression of PtoABCG36 in tobacco showed that PtoABCG36 is localized at the plasma membrane. When overexpressed in yeast and Arabidopsis, PtoABCG36 could decrease Cd accumulation and confer higher Cd tolerance in transgenic lines than in wild-type (WT) lines. Net Cd2+ efflux measurements showed a decreasing Cd uptake in transgenic Arabidopsis roots than WT. These results demonstrated that PtoABCG36 functions as a cadmium extrusion pump participating in enhancing tolerance to Cd through decreasing Cd content in plants, which provides a promising way for making heavy metal tolerant poplar by manipulating ABC transporters in cadmium polluted areas.
- Published
- 2019
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21. Identification and Rational Engineering of a High Substrate‐Tolerant Leucine Dehydrogenase Effective for the Synthesis of L‐tert‐Leucine.
- Author
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Meng, Xiangqi, Yang, Lin, Liu, Yan, Wang, Hualei, Shen, Yaling, and Wei, Dongzhi
- Subjects
AMINO acid synthesis ,LEUCINE ,SEQUENCE alignment ,NAD (Coenzyme) ,PYRUVATES - Abstract
The asymmetric synthesis of chiral amino acids by leucine dehydrogenases has great potential for industrialization; however, the inhibitory effect of high‐concentration substrates limits its large‐scale application. Herein, using structure‐guided genome mining based on sequence‐structure prediction of substrate tolerance and specificity, a novel leucine dehydrogenase (LaLeuDH) from Labrenzia aggregate was identified and characterized, which exhibited the highest substrate tolerance and excellent activity to trimethyl pyruvate, even at 1.5 M concentration. Moreover, based on coenzyme binding structural information and sequence alignment, directed evolution of LaLeuDH was performed to increase affinity for NADH. The obtained variant D153 N/H191 N resulted in 25‐fold improved affinity for NADH, with 50‐fold enhanced catalytic efficiency (kcat/Km) of 40464.6 mM−1 s−1. Finally, through a combination of the above two strategies, as high as 1.5 M substrate could be completely converted in 18 h without coenzyme addition, demonstrating that this engineered enzyme has promising prospects for industrialization. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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22. Oxygen vacancy–engineered δ-MnO /activated carbon for room-temperature catalytic oxidation of formaldehyde
- Author
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Wei Wang, Haiwei Li, Meijuan Chen, Yu Huang, Shuncheng Lee, Liu Yan, Tingting Huang, Wingkei Ho, and Junji Cao
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biology ,Process Chemistry and Technology ,Formaldehyde ,Active site ,chemistry.chemical_element ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Photochemistry ,01 natural sciences ,Oxygen ,Catalysis ,0104 chemical sciences ,chemistry.chemical_compound ,Adsorption ,chemistry ,Catalytic oxidation ,biology.protein ,medicine ,0210 nano-technology ,Selectivity ,General Environmental Science ,Activated carbon ,medicine.drug - Abstract
Although oxygen vacancies (OVs) commonly act as adsorption/active sites in catalytic oxidation of formaldehyde (HCHO), thereby strongly influencing catalyst activity, their control and translation into scale-up products for practical application remain challenging. Herein, δ-MnOx/activated carbon was synthesized via in situ reduction coupled with ammonia modification, and the developed method was found to allow easy OV control for large-scale production. OV concentration was effectively regulated through adjustment of Mn3+ content, and OV roles in the catalytic reaction were probed by several techniques. The optimized catalyst featured superior HCHO removal efficiency and CO2 selectivity at room temperature, mainly due to oxygen activation by abundant OVs to form reactive oxygen species. The intermediates and pathways of HCHO removal were investigated. Thus, this work provides insights into the enhancement of active site exposure through OV control for a single bulk catalyst and demonstrates its applicability for efficient and commercially viable room-temperature oxidation of HCHO.
- Published
- 2020
23. Alkoxide Trap in Transition‐Metal‐Catalyzed Dehydrogenative Coupling and Borrowing Hydrogen Reactions.
- Author
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Vignesh, Arumugam, Wang, Zhe, Liu, Yan, and Ke, Zhuofeng
- Subjects
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CATALYST poisoning , *ORGANIC synthesis , *TRANSITION metals , *CATALYSIS , *ALKYLATION - Abstract
Dehydrogenative coupling (DC) and borrowing hydrogen(ation) (BH) reactions are crucial in modern organic synthesis, offering efficient and sustainable ways to create valuable compounds. However, they often face a significant challenge: the alkoxide trap. This Concept explores the alkoxide trap in DC and BH reactions, starting with the basic mechanisms and the role of alkoxide intermediates. It then examines how the alkoxide trap leads to catalyst deactivation and reduced selectivity, influenced by thermodynamic and kinetic factors. To address this, we review recent advances in catalyst design, ligand engineering, and optimized reaction conditions, along with the use of in‐situ spectroscopy and computational modelling, to better understand the underlying processes and guide rational catalyst development. Furthermore, this Concept highlights the broad applicability of DC, and BH reactions across various substrates, underscoring the urgency of addressing the alkoxide trap issue to unlock their full synthetic potential. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
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24. Liposome-assisted enzyme catalysis: toward signal amplification for sensitive split-type electrochemiluminescence immunoassay.
- Author
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Fu, Yi-Zhuo, Liu, Xiang-Mei, Ma, Shu-Hui, Cao, Jun-Tao, and Liu, Yan-Ming
- Subjects
CHEMILUMINESCENCE immunoassay ,CATALYSIS ,PROSTATE-specific antigen ,ELECTROCHEMILUMINESCENCE ,CARBON electrodes ,IMMUNOASSAY ,GLUCOSE oxidase ,EXONUCLEASES - Abstract
Developing an efficient signal amplification strategy is very important to improve the sensitivity of bioanalysis. In this paper, a liposome-assisted enzyme catalysis signal amplification strategy was developed for electrochemiluminescence (ECL) immunoassay of prostate specific antigen (PSA) in a split-type mode. The sandwich immunoreaction occurred in a 96-well plate, and glucose oxidase (GOx) encapsulated and antibody-modified liposomes were used as labels. The ECL detection was carried out using a rGO-Au NP modified glassy carbon electrode (GCE). The large amount of generated H
2 O2 , i.e. the coreactant of the luminol system, and the excellent catalytic behavior of rGO-Au NPs greatly boosted the ECL signal, resulting in the signal amplification. The developed ECL immunosensor for detecting PSA achieved a wider linear range from 1.0 × 10−13 to 1.0 × 10−8 g mL−1 and a detection limit of 1.7 × 10−14 g mL−1 . The application of the proposed strategy was demonstrated by analyzing PSA in human serum samples with recoveries from 89.0% to 113.0%, and relative standard deviations (RSDs) were less than 6.6%. This work provides a new horizon to expand the application of liposomes for ECL bioanalysis. [ABSTRACT FROM AUTHOR]- Published
- 2021
- Full Text
- View/download PDF
25. Ultrasound-assisted heterogeneous activation of peroxymonosulphate by natural pyrite for 2,4-diclorophenol degradation in water: Synergistic effects, pathway and mechanism
- Author
-
Fu Xin Dong, Zeng Hui Diao, Xi Zhen Chen, Ling Jun Kong, Wei Chu, Liu Yan, Zi Yu Lin, Wei Qian, and Jian Jun Du
- Subjects
Maleic acid ,Hydroquinone ,General Chemical Engineering ,Oxalic acid ,2,4-Dichlorophenol ,02 engineering and technology ,General Chemistry ,engineering.material ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Industrial and Manufacturing Engineering ,0104 chemical sciences ,Sonochemistry ,Catalysis ,Hydroxylation ,chemistry.chemical_compound ,chemistry ,engineering ,Environmental Chemistry ,Pyrite ,0210 nano-technology ,Nuclear chemistry - Abstract
In this paper, the natural pyrite was firstly used as peroxymonosulphate (PMS) activator in conjunction with ultrasonic irradiation (US) for 2,4-dichlorophenol (2,4-DCP) degradation in water. The most relevant findings indicated that a superior degradation of 2,4-DCP has been successfully achieved in pyrite/PMS/US system compared with pyrite/PMS and/or pyrite/US systems, which involved a synergistic effect between sonolysis and Fenton-like reaction. Within 120 min, nearly 98% of 2,4-DCP could be degraded at optimum reaction conditions of pyrite 1.00 g L−1, 2,4-DCP 10 mg L−1, PMS 2.00 mM and pH 4.02. A significantly enhanced PMS decomposition was probably ascribed to the sonochemistry (PMS/US and pyrite/US systems) and catalytic chemistry (pyrite/PMS system) under acidic conditions. Both SO4 − and HO took part in reaction process, while the SO4 − was dominant for 2,4-DCP degradation. A total of six intermediate products including 3,5-dichlorocatechol, 2-chlorophenol, 4-chlorocatechol, hydroquinone, maleic acid and oxalic acid were identified using GC/MS analyses to clarify the possible degradation pathways, which involved hydroxylation and substitution reactions. Compared to other Fenton reaction systems, both maximum degradation and mineralization levels of 2,4-DCP have been obtained from pyrite/PMS/US system. This study provides an interesting insight for PMS activation by the natural mineral-based catalyst with US irradiation for in situ organic pollutants remediation.
- Published
- 2020
26. Retraction Note: A New Porous Metal–Organic Framework Constructed from 2, 5-Thiophenedicarboxylate and Melamine Ligands: Catalysis Dye Degradation and Anti-tumor Activity in Myocardioma.
- Author
-
Liu, Yan, Ao, Xue-Ling, Jiao, Pi-Qi, Wang, Fei, and Ma, Ling
- Subjects
- *
METAL-organic frameworks , *ANTINEOPLASTIC agents , *LIGANDS (Chemistry) , *CATALYSIS , *COORDINATE covalent bond , *MELAMINE - Abstract
The article titled "Retraction Note: A New Porous Metal–Organic Framework Constructed from 2, 5-Thiophenedicarboxylate and Melamine Ligands: Catalysis Dye Degradation and Anti-tumor Activity in Myocardioma" has been retracted by the Editor-in-Chief and the Publisher of the Journal of Cluster Science. The retraction was prompted by evidence of systematic manipulation of the publication process, including issues with citations, phrasing, figures, and ethics approval statements. The authors have not responded to correspondence regarding the retraction. Springer Nature, the publisher, remains neutral in regards to jurisdictional claims and institutional affiliations. [Extracted from the article]
- Published
- 2024
- Full Text
- View/download PDF
27. Directed modification of l-LcLDH1, an l-lactate dehydrogenase from Lactobacillus casei, to improve its specific activity and catalytic efficiency towards phenylpyruvic acid
- Author
-
Zhang Ting, Ji-Ru Zhang, Min-Chen Wu, Jianfang Li, Li Xueqing, Liu Yan, and Yuan Fengjiao
- Subjects
0106 biological sciences ,0301 basic medicine ,Lactobacillus casei ,Stereochemistry ,Phenylpyruvic Acids ,Bioengineering ,Dehydrogenase ,medicine.disease_cause ,Protein Engineering ,01 natural sciences ,Applied Microbiology and Biotechnology ,Catalysis ,03 medical and health sciences ,chemistry.chemical_compound ,Bacterial Proteins ,010608 biotechnology ,medicine ,Escherichia coli ,Enzyme kinetics ,Enantiomeric excess ,chemistry.chemical_classification ,biology ,L-Lactate Dehydrogenase ,Chemistry ,Phenylpyruvic acid ,General Medicine ,biology.organism_classification ,Molecular Docking Simulation ,Lacticaseibacillus casei ,030104 developmental biology ,Enzyme ,Mutation ,Mutagenesis, Site-Directed ,Specific activity ,Biotechnology - Abstract
To improve the specific activity and catalytic efficiency of l-LcLDH1, an NADH-dependent allosteric l-lactate dehydrogenase from L. casei, towards phenylpyruvic acid (PPA), its directed modification was conducted based on the semi-rational design. The three variant genes, Lcldh1Q88R, Lcldh1I229A and Lcldh1T235G, were constructed by whole-plasmid PCR as designed theoretically, and expressed in E. coli BL21(DE3), respectively. The purified mutant, l-LcLDH1Q88R or l-LcLDH1I229A, displayed the specific activity of 451.5 or 512.4 U/mg towards PPA, by which the asymmetric reduction of PPA afforded l-phenyllactic acid (PLA) with an enantiomeric excess (eep) more than 99%. Their catalytic efficiencies (kcat/Km) without d-fructose-1,6-diphosphate (d-FDP) were 4.8- and 5.2-fold that of l-LcLDH1. Additionally, the kcat/Km values of l-LcLDH1Q88R and l-LcLDH1I229A with d-FDP were 168.4- and 8.5-fold higher than those of the same enzymes without d-FDP, respectively. The analysis of catalytic mechanisms by molecular docking (MD) simulation indicated that substituting I229 in l-LcLDH1 with Ala enlarges the space of substrate-binding pocket, and that the replacement of Q88 with Arg makes the inlet of pocket larger than that of l-LcLDH1.
- Published
- 2018
28. Synthesis of Terphenyl Derivatives by Pd-Catalyzed Suzuki-Miyaura Reaction of Dibromobenzene Using 2N2O-Salen as a Ligand in Aqueous Solution
- Author
-
Bin Dai, Yashuai Liu, Liu Yan, Ping Liu, Ningning Gu, and Xiaowei Ma
- Subjects
Steric effects ,chemistry.chemical_compound ,Aqueous solution ,Chemistry ,Ligand ,Terphenyl ,chemistry.chemical_element ,Organic chemistry ,General Chemistry ,Medicinal chemistry ,Catalysis ,Palladium - Abstract
A simple and efficient catalytic system for Na2PdCl4 catalyzing the Suzuki-Miyaura reaction of dibromobenzene and arylboronic acid has been developed by using 2N2O-salen as a ligand in H2O/EtOH (V:V=4:1) at 100°C. Using this method, the reactions of substrates containing sterically demanding ortho substituents (e.g. dibromobenzene and/or arylboronic acids) proceeded efficiently, with the corresponding terphenyl derivatives being produced in moderate to excellent yields. Furthermore, this method offers interesting features for the multi-gram scale synthesis of terphenyl compound.
- Published
- 2015
29. Model of iron ore sintering based on melt and mineral formation
- Author
-
Xing-min Guo, Ding-liu Yan, Yuan-hong Qi, and Jun Zhang
- Subjects
Materials science ,Mineral ,Metallurgy ,Metals and Alloys ,Sintering ,Hematite ,engineering.material ,Combustion ,Decomposition ,Catalysis ,chemistry.chemical_compound ,chemistry ,Iron ore ,Mechanics of Materials ,visual_art ,Materials Chemistry ,visual_art.visual_art_medium ,engineering ,Magnetite - Abstract
A model of iron ore sintering was built with consideration of fuel combustion, catalysis of sinter mixture as well as formation of melt and mineral, which was verified via sintering pot tests and showed a good fit to the experimental results. The effect of bed depth on temperature was reflected by the residence time in high-temperature zone, rather than the top value of the temperature, which was weakened by melt formation as well as hematite decomposition. Moreover, the effect of bed depth, fuel content and distribution on sintering process was different, which was reflected by temperature profiles and the rule of calcium ferrite formation. The formation of melt as well as magnetite was a process which was decided by kinetic factors, while the formation of calcium ferrite was related to fuel blending conditions, which is determined by thermodynamics when the fuel ratio inside sinter granules is low or fuel content is high, otherwise, it is determined by kinetics.
- Published
- 2015
30. Confinement‐Driven Enantioselectivity in 3D Porous Chiral Covalent Organic Frameworks.
- Author
-
Hou, Bang, Yang, Shi, Yang, Kuiwei, Han, Xing, Tang, Xianhui, Liu, Yan, Jiang, Jianwen, and Cui, Yong
- Subjects
BRONSTED acids ,CATALYSIS ,BINAPHTHOL ,ENANTIOSELECTIVE catalysis ,CATALYSTS ,ALDEHYDES - Abstract
3D covalent organic frameworks (COFs) with well‐defined porous channels are shown to be capable of inducing chiral molecular catalysts from non‐enantioselective to highly enantioselective in catalyzing organic transformations. By condensations of a tetrahedral tetraamine and two linear dialdehydes derived from enantiopure 1,1′‐binaphthol (BINOL), two chiral 3D COFs with a 9‐fold or 11‐fold interpenetrated diamondoid framework are prepared. Enhanced Brønsted acidity was observed for the chiral BINOL units that are uniformly distributed within the tubular channels compared to the non‐immobilized acids. This facilitates the Brønsted acid catalysis of cyclocondensation of aldehydes and anthranilamides to produce 2,3‐dihydroquinazolinones. DFT calculations show the COF catalyst provides preferential secondary interactions between the substrate and framework to induce enantioselectivities that are not achievable in homogeneous systems. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
31. Allylsilane Reagent‐Controlled Divergent Asymmetric Catalytic Reactions of 2‐Naphthoquinone‐1‐methide.
- Author
-
Lin, Xiangfeng, Liu, Yan, and Li, Can
- Subjects
- *
ALLYLATION , *NATURAL products , *DIELS-Alder reaction , *CATALYSIS , *DIARYL compounds - Abstract
Herein, the first allylsilane reagent‐controlled divergent asymmetric Hosomi–Sakurai conjugate allylation and hetero‐Diels–Alder (HDA) with 2‐naphthoquinone‐1‐methide (2‐Nap‐Q‐1‐M) under the catalysis of ScIII/Feng ligand complex is reported. With these methods, a variety of uniquely substituted chiral allyl‐functionalized diaryl compounds and naphthopyran products were obtained in a straightforward and highly stereoselective (up to 96.5:3.5 e.r.) manner under mild conditions. Moreover, it is demonstrated that 2‐Nap‐Q‐1‐M can serve as an efficient diene for a side asymmetric Diels–Alder (D‐A) reaction. This principle can provide a straightforward access to hydrophenalene in an optically active form, which represents a structural core of various natural products and bioactive molecules. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
32. Synthesis of Novel 1,4-Substituted 1,2,3-Triazoles by Water-Soluble (Salicyladimine) 2Cu Complex Catalyzed Azide-Alkyne Cycloaddition in Water
- Author
-
Liu Ping, Liu Yang, Liu Yan, and Wei Yu
- Subjects
chemistry.chemical_classification ,010405 organic chemistry ,Organic Chemistry ,Alkyne ,010402 general chemistry ,01 natural sciences ,Biochemistry ,Cycloaddition ,0104 chemical sciences ,Catalysis ,chemistry.chemical_compound ,Water soluble ,chemistry ,Polymer chemistry ,Azide - Published
- 2017
33. Direct hydro-liquefaction of sawdust in petroleum ether and comprehensive bio-oil products analysis
- Author
-
Dong Liu, Linhua Song, Qingyin Li, Zifeng Yan, Liu Yan, and Pingping Wu
- Subjects
Time Factors ,Environmental Engineering ,Analytical chemistry ,Lignocellulosic biomass ,Bioengineering ,Fraction (chemistry) ,Mass spectrometry ,Lignin ,Catalysis ,Gas Chromatography-Mass Spectrometry ,Fourier transform ion cyclotron resonance ,chemistry.chemical_compound ,Alkanes ,Petroleum ether ,Waste Management and Disposal ,Renewable Energy, Sustainability and the Environment ,Liquefaction ,General Medicine ,Wood ,Models, Chemical ,chemistry ,Chemical engineering ,Biofuels ,visual_art ,Yield (chemistry) ,visual_art.visual_art_medium ,Sawdust - Abstract
The effect of temperature, time, hydrogen pressure and amount of catalyst on production distribution and the bio-oil yield obtained from the direct liquefaction of sawdust in the petroleum ether (60-90°C) are investigated. The highest sawdust conversion obtained was 72.32% with a bio-oil yield of 47.69% were obtained at 370°C, 40min and 5wt.% catalyst content with the initial H2 pressure of 3.0MPa. Fourier transform ion cyclotron resonance mass spectrometry (FTICR-MS) approach was utilized to analyze the non-volatile fraction. In this study, the composition of bio-oil could be analyzed in an unprecedented detail through a combination of GC-MS and FT-ICR MS techniques.
- Published
- 2014
34. Chiral covalent organic frameworks: design, synthesis and property.
- Author
-
Han, Xing, Yuan, Chen, Hou, Bang, Liu, Lujia, Li, Haiyang, Liu, Yan, and Cui, Yong
- Subjects
CHIRAL recognition ,POROUS materials ,COVALENT bonds ,CATALYSIS ,CHEMISTRY - Abstract
Covalent organic frameworks (COFs) are constructed using reticular chemistry with the building blocks being connected via covalent bonds and have emerged as a new series of porous materials for multitudinous applications. Most COFs reported to date are achiral, and only a small fraction of COFs with chiral nature are reported. This review covers the recent advances in the field of chiral COFs (CCOFs), including their design principles and synthetic strategies, structural studies, and potential applications in asymmetric catalysis, enantioselective separation, and chiral recognition. Finally, we illustrate the remaining challenges and future opportunities in this field. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
35. Practical Synthesis of High‐Performance Amino Tf‐Amide Organocatalysts for Asymmetric Aldol Reactions.
- Author
-
Lu, Hanbin, Lv, Jiamin, Zhou, Canhua, Kato, Terumasa, Liu, Yan, and Maruoka, Keiji
- Subjects
ALDOLS ,CHEMICAL adducts ,ORGANOCATALYSIS ,CATALYSTS ,CATALYSIS - Abstract
A type of optically pure secondary‐amino aromatic Tf‐amide organocatalysts can be easily prepared from commercially available L‐hydroxyproline. The chemical behavior of these organocatalysts was investigated by the application to asymmetric aldol reactions. Among these, catalyst 2 a efficiently catalyzed direct asymmetric aldol reactions of cycloalkanones and substituted benzaldehydes, which afforded the corresponding aldol adducts in good yield with good to excellent anti‐diastereo and enantioselectivity. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
36. A New Porous Metal–Organic Framework Constructed from 2, 5-Thiophenedicarboxylate and Melamine Ligands: Catalysis Dye Degradation and Anti-tumor Activity in Myocardioma.
- Author
-
Liu, Yan, Ao, Xue-Ling, Jiao, Pi-Qi, Wang, Fei, and Ma, Ling
- Subjects
- *
METAL-organic frameworks , *CATALYSIS , *PORE size distribution , *ORGANIC acids , *LIGANDS (Chemistry) , *MELAMINE - Abstract
A new three-dimensional transition Co(II)–organic framework {[Co2L2MA]·(DMA)(MeOH)}n (MA = melamine, H2L = 2,5-thiophenedicarboxylic acid) bearing the rigid S-containing organic ligand 2,5-thiophenedicarboxylic acid and the N-rich organic linker melamine has been synthesized and structurally characterized. The presence of abundant micropores in the resulting activated 1a has been confirmed via the N2 sorption experiments at 77 K, which reflects a BET surface area of 925 m2/g and a pore size distribution of 7.4 Å. Furthermore, the catalytic activities of complex 1 for the degradation of methyl orange in a Fenton-like process have also investigated, which reveals that complex 1 could behave as effective as heterogeneous catalyst to activate persulfate anions and to degrade methyl orange. To evaluate the inhibitory effect of compound 1 on H9C2 myocardioma cells, the viability of cells after compound treatment was detected by CCK-8 assay, and the proliferation of cells were observed by colony formation assay. Next, the detail mechanism of compound 1 was further explored, the western blot was performed to determine the relative expression of apoptotic protein Blc-2 and Bax. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
37. Chiral Phosphoric Acids in Metal–Organic Frameworks with Enhanced Acidity and Tunable Catalytic Selectivity.
- Author
-
Chen, Xu, Jiang, Hong, Li, Xu, Hou, Bang, Gong, Wei, Wu, Xiaowei, Han, Xing, Zheng, Fanfan, Liu, Yan, Jiang, Jianwen, and Cui, Yong
- Subjects
METAL-organic frameworks ,PHOSPHORIC acid ,ACIDITY ,CATALYSIS ,CONDENSATION - Abstract
Chiral phosphoric acids are incorporated into indium‐based metal–organic frameworks (In‐MOFs) by sterically preventing them from coordination. This concept leads to the synthesis of three chiral porous 3D In‐MOFs with different network topologies constructed from three enantiopure 1,1′‐biphenol‐phosphoric acid derived tetracarboxylate linkers. More importantly, all the uncoordinated phosphoric acid groups are periodically aligned within the channels and display significantly enhanced acidity compared to the non‐immobilized acids. This facilitates the Brønsted acid catalysis of asymmetric condensation/amine addition and imine reduction. The enantioselectivities can be tuned (up to >99 % ee) by varying the substituents to achieve a nearly linear correlation with the concentrations of steric bulky groups in the MOFs. DFT calculations suggest that the framework provides a chiral confined microenvironment that dictates both selectivity and reactivity of chiral MOFs. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
38. Immobilization of Cinchona Quaternary Ammonium Salts as the Chiral Phase Transfer Catalysts on Multi-walled Carbon Nanotubes and Their Application in Enantioselective Alkylation
- Author
-
Liu Yan, Yang Qihua, Liu Jian, and Shi Xin
- Subjects
biology ,Chemistry ,Enantioselective synthesis ,Cinchona ,General Chemistry ,Alkylation ,biology.organism_classification ,Toluene ,Catalysis ,chemistry.chemical_compound ,Adsorption ,Desorption ,Organic chemistry ,Halohydrocarbon - Abstract
The pyrene-tagged cinchona quaternary ammonium salt, the chiral phase transfer catalysts (PTC-1), was synthesized and immobilized on multi-walled carbon nanotubes (MWCNTs). The new catalysts (PTC-1/MWCNTs) were employed in enantioselective alkylation of N-(diphenylmethyene)glycine tert-butyl ester. UV-Vis absorption spectra show the effect of different organic solvents on the adsorption and desorption of PTC-1 onto and from MWCNTs, respectively. The results show that 5.3 mg PTC-1 can be loaded on 10 mg MWCNTs in toluene, and 0.02025 mg PTC-1 was desorbed from 12.7 mg PTC-1/MWCNTs when washed by CHCl3. In the enantioselective alkylation of different halohydrocarbons with N-(diphenylmethyene)glycine tert-butyl ester using PTC-1/MWCNTs as a catalyst, the alkylating products were obtained with high yield and ee value. Furthermore, PTC-1/MWCNTs catalyst can be recovered and used repeatedly. PTC-1/MWCNTs as a new catalyst is effective in enantioselective alkylation of multiple halohydrocarbon.
- Published
- 2013
39. Low-Temperature Performances for Monolithic V2O5-WO3/TiO2 Catalyst in the NH3-SCR System
- Author
-
Li Cailing, Liu Yan, Zhu Yuanqing, Yu Yan, and Zhou Song
- Subjects
Diesel fuel ,Chemical engineering ,Chemistry ,Desorption ,General Chemistry ,Slip (materials science) ,Space velocity ,Catalysis - Abstract
According to the working characteristics of marine diesel engines, a SCR catalyst testing system was developed and catalytic activities of an extruded commercial monolithic V2O5-WO3/TiO2 catalyst at low temperatures were studied in this paper. Meanwhile, key parameters including catalytic temperature, space velocity, NH3 consumption, excess O-2 and NO2 concentration in the gas mixtures were also analyzed to enhance the low-temperature performances of marine SCR systems. It is found that desorption reaction of NH3 absorbed on the catalyst surface may be responsible for a sharply increasing of NH3 slip in a short time, which could also lead to the secondary pollution of NH3 from the SCR system.
- Published
- 2013
40. ChemInform Abstract: Synthesis of Terphenyl Derivatives by Pd-Catalyzed Suzuki-Miyaura Reaction of Dibromobenzene Using 2N2O-Salen as a Ligand in Aqueous Solution
- Author
-
Bin Dai, Liu Yan, Ningning Gu, Xiaowei Ma, Yashuai Liu, and Ping Liu
- Subjects
Steric effects ,chemistry.chemical_compound ,Aqueous solution ,chemistry ,Ligand ,Terphenyl ,General Medicine ,Medicinal chemistry ,Catalysis - Abstract
A simple and efficient catalytic system for Na2PdCl4 catalyzing the Suzuki-Miyaura reaction of dibromobenzene and arylboronic acid has been developed by using 2N2O-salen as a ligand in H2O/EtOH (V:V=4:1) at 100°C. Using this method, the reactions of substrates containing sterically demanding ortho substituents (e.g. dibromobenzene and/or arylboronic acids) proceeded efficiently, with the corresponding terphenyl derivatives being produced in moderate to excellent yields. Furthermore, this method offers interesting features for the multi-gram scale synthesis of terphenyl compound.
- Published
- 2016
41. Kinetics investigation of the hydrogen abstraction reaction between CH3SS and CN radicals
- Author
-
Liu Yan, Wang Wen-Liang, Liu Zhongwen, and Ren Hongjiang
- Subjects
Arrhenius equation ,Reaction mechanism ,010304 chemical physics ,Chemistry ,Organic Chemistry ,Activation energy ,010402 general chemistry ,01 natural sciences ,Catalysis ,Transition state ,0104 chemical sciences ,Computer Science Applications ,Gibbs free energy ,Inorganic Chemistry ,symbols.namesake ,Transition state theory ,Reaction rate constant ,Computational Theory and Mathematics ,0103 physical sciences ,Potential energy surface ,symbols ,Physical chemistry ,Physical and Theoretical Chemistry - Abstract
The reaction mechanisms and rates for the H abstraction reactions between CH3SS and CN radicals in the gas phase were investigated with density functional theory (DFT) methods. The geometries, harmonic vibrational frequencies, and energies of all stationary points were obtained at B3PW91/6-311G(d,p) level of theory. Relationships between the reactants, intermediates, transition states and products were confirmed, with the frequency and the intrinsic reaction coordinate (IRC) analysis at the same theoretical level. High accurate energy information was provided by the G3(MP2) method combined with the standard statistical thermodynamics. Gibbs free energies at 298.15 K for all of the reaction steps were reported, and were used to describe the profile diagrams of the potential energy surface. The rate constants were evaluated with both the classical transition state theory and the canonical variational transition state theory, in which the small-curvature tunneling correction was included. A total number of 9 intermediates (IMs) and 17 transition states (TSs) were obtained. It is shown that IM1 is the most stable intermediate by the largest energy release, and the channel of CH3SS + CN → IM3 → TS10 → P1(CH2SS + HCN) is the dominant reaction with the lowest energy barrier of 144.7 kJ mol(-1). The fitted Arrhenius expressions of the calculated CVT/SCT rate constants for the rate-determining step of the favorable channel is k =7.73 × 10(6) T (1.40)exp(-14,423.8/T) s(-1) in the temperature range of 200-2000 K. The apparent activation energy E a(app.) for the main channel is -102.5 kJ mol(-1), which is comparable with the G3(MP2) energy barrier of -91.8 kJ mol(-1) of TS10 (relative to the reactants).
- Published
- 2016
42. Study on the Preparation of Dy-Doped TiO2 Nanotube Arrays and its Visible Light Responsive Photocatalytic Properties
- Author
-
Yu Jiang Guan, Zi Bo Wang, Shu Li Bai, and Liu Yan Su
- Subjects
Materials science ,Doping ,Nanotechnology ,General Medicine ,Catalysis ,chemistry.chemical_compound ,Chemical engineering ,X-ray photoelectron spectroscopy ,chemistry ,Titanium dioxide ,Photocatalysis ,Methyl orange ,Degradation (geology) ,Visible spectrum - Abstract
The in-suit Dy-doped titanium dioxide nanotubes arrays were prepared by anodic oxidation method using Dy (NO3)3·6H2O and pure Ti sheet. The sample was characterized by SEM, XRD and XPS for its size and structure. The photocatalytic properties of nanotubes arrays were researched by using methyl orange as target degradation under the visible light. The results showed that the catalytic activity of Dy-doped titanium dioxide nanotubes arrays was 72% under visible light. The catalyst has hight stability and potential industrial applications.
- Published
- 2011
43. Supramolecular Coordination Cages for Asymmetric Catalysis.
- Author
-
Tan, Chunxia, Chu, Dandan, Tang, Xianhui, Liu, Yan, Xuan, Weimin, and Cui, Yong
- Subjects
SUPRAMOLECULAR chemistry ,CATALYSIS ,COORDINATE covalent bond ,CATALYSTS ,ENZYMES - Abstract
Inspired by the high efficiency and specificity of enzymes in living systems, the development of artificial catalysts intrinsic to the key features of enzyme has emerged as an active field. Recent advances in supramolecular chemistry have shown that supramolecular coordination cages, built from non‐covalent coordination bonds, offer a diverse platform for enzyme mimics. Their inherent confined cavity, analogous to the binding pocket of an enzyme, and the facile tunability of building blocks are essential for substrate recognition, transition‐state stabilization, and product release. In particular, the combination of chirality with supramolecular coordination cages will undoubtedly create an asymmetric microenvironment for promoting enantioselective transformation, thus providing not only a way to make synthetically useful asymmetric catalysts, but also a model to gain a better understanding for the fundamental principles of enzymatic catalysis in a chiral environment. The focus here is on recent progress of supramolecular coordination cages for asymmetric catalysis, and based on how supramolecular coordination cages function as reaction vessels, three approaches have been demonstrated. The aim of this review is to offer researchers general guidance and insight into the rational design of sophisticated cage containers for asymmetric catalysis. Trapped in confined spaces: Supramolecular coordination cages feature an inherent confined cavity analogous to the binding pocket of enzymes. Coupled with chirality, supramolecular coordination cages provide a way to prepare synthetically useful asymmetric catalysts. Based on how supramolecular coordination cages function as reaction vessels, several approaches are demonstrated. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
44. Auto‐Tandem Catalysis with Ruthenium: From o‐Aminobenzamides and Allylic Alcohols to Quinazolinones via Redox Isomerization/Acceptorless Dehydrogenation.
- Author
-
Zhang, Weikang, Meng, Chong, Liu, Yan, Tang, Yawen, and Li, Feng
- Subjects
CATALYSIS ,RUTHENIUM ,BENZAMIDE ,ALLYL alcohol ,QUINAZOLINONES ,ISOMERIZATION ,DEHYDROGENATION - Abstract
Abstract: A strategy for the synthesis of quinazolinones via Ru‐catalyzed redox isomerization/acceptorless dehydrogenation was proposed and accomplished. In the presence of a commercially available [(p‐cymene)Cl
2 ]2 , a range of desirable products were obtained with o‐aminobenzamides and allylic alcohols as starting materials in moderate to high yields. This strategy is attractive due to high atom efficiency, and minimal consumption of chemicals and energy. [ABSTRACT FROM AUTHOR]- Published
- 2018
- Full Text
- View/download PDF
45. Aerobic selective oxidation of alcohols to aldehydes or ketones catalyzed by ionic liquid immobilized TEMPO under solvent-free conditions
- Author
-
Yunyang Wei, Lin Liu, and Liu-Yan Ji
- Subjects
chemistry.chemical_compound ,Solvent free ,Chemistry ,Alcohol oxidation ,Ionic liquid ,Inorganic chemistry ,Organic chemistry ,General Chemistry ,Molecular oxygen ,Catalysis - Abstract
A selective ionic-liquid immobilized TEMPO/CuCl catalyzed oxidation procedure of alcohols to the corresponding aldehydes and ketones with molecular oxygen under solvent-free conditions was developed. The catalyst was easily recovered and reused in the reaction.
- Published
- 2008
46. Recycling Chiral Organocatalyst (4S)-Phenoxy-(S)-proline for Direct Asymmetric Aldol Reaction in Ionic Liquid (bmim)PF6
- Author
-
Zhang Ya-wen, Ding Yi-Ping, Liu Yan-Hua, Luo Xiao-Qing, and Shen Zong-Xuan
- Subjects
chemistry.chemical_compound ,Aldol reaction ,Chemistry ,Extraction (chemistry) ,Ionic liquid ,Organic chemistry ,General Chemistry ,Proline ,Catalysis - Abstract
Room temperature ionic liquid (bmim)PF6 was evaluated for recycling an organocatalyst (4S)-phenoxy-(S)-proline for direct asymmetric aldol reactions. The desired aldol products were obtained with good yields up to 93.2% and enantioselectivities up to 88.5%, and isolation of the products by simple extraction allowed recycling the ionic liquid containing the immobilized catalyst in subsequent reactions without significant decrease of yields and enantioselectivities.
- Published
- 2005
47. Effect of Protective Agents upon the Catalytic Property of Platinum Nanocrystals.
- Author
-
Yan, Muyu, Wu, Tong, Liu, Bo, Lian, Chao, Chen, Lifang, Yu, Yulv, Wang, Yuan, Liu, Yan, Chen, Wenxing, and Li, Yadong
- Subjects
NANOCRYSTALS ,PLATINUM nanoparticles ,CATALYSIS ,HYDROGENATION ,POLYVINYL alcohol ,POVIDONE - Abstract
Abstract: “Unprotected” Pt nanocrystals were modified with triphenylphosphine (PPh
3 ), octadecylamine (ODA), poly(vinylpyrrolidone) (PVP), poly(vinyl alcohol) (PVA), and dodecanethiol (DT) to investigate the effect of protective agents on the intrinsic catalytic property of Pt nanocrystals. By evaluating the catalytic performance of these model catalysts for the hydrogenation of para‐chloronitrobenzene (p‐CNB), it was found that direct or indirect interaction between nanocrystals and protective agents imposed a great impact on the catalytic performance of the nanocrystals. Protective agents with different electron‐donating ability (PPh3 , ODA, PVP, and PVA) directly altered surface electronic state of Pt nanocrystals to bring the surface Pt atoms into an electron‐rich state, which would exert influence on the hydrogenation course by changing the adsorption and the reactivity of reactant, intermediates, and products. In contrast, DT exerted an indirect influence on the Pt nanocrystals. The coordinated Pt atoms were oxidized by DT to generate cationic Pt species on the surface of nanocrystals, and the cationic species would simultaneously improve the hydrogenation rate and selectivity to para‐chloroaniline by polarizing the N=O bond in the −NO2 group of p‐CNB and altering the electronic state of Pt nanocrystals, respectively. This work provided further insights into nanocatalysis, which is helpful for further design and application of highly efficient nanocrystal catalysts. [ABSTRACT FROM AUTHOR]- Published
- 2018
- Full Text
- View/download PDF
48. Enzymatic catalyzed corn fiber gum-bovine serum albumin conjugates: Their interfacial adsorption behaviors in oil-in-water emulsions.
- Author
-
Liu, Yan, Yadav, Madhav P., and Yin, Lijun
- Subjects
- *
CATALYSIS , *ALBUMINS , *ADSORPTION (Chemistry) , *PROTEINS , *POLYSACCHARIDES - Abstract
The purpose of present study was to investigate the interfacial behaviors of the peroxidase-catalyzed intermolecular conjugates of corn fiber gum (CFG) and bovine serum albumin (BSA) (gum and protein weight ratio of 4:1). CFG-BSA conjugate stabilized emulsion remained stable with low flocculation and coalescence degree during storage in comparison to single BSA or CFG emulsion, attributing to its higher amount of adsorbed protein and polysaccharide. As shown by SDS-sulfate polyacrylamide gel electrophoresis, the adsorbed protein at the surface of oil droplets stabilized by CFG-BSA conjugate was partly crosslinked with CFG, forming an entangled emulsion network with increased apparent viscosity. Adsorbed CFG-BSA conjugates distributed loosely around the droplet interfaces as revealed by images of confocal laser scanning microscopy. Their interfacial layer thickness was estimated to be 85.1 nm using a monodisperse polystyrene latex particle model, which was not only larger than the adsorbed layer thickness of single CFG (71 nm) or BSA (6.9 nm) but also their combined layer thickness. To our knowledge, it is the first time that the interfacial properties of enzymatically-crosslinked polysaccharide and protein have been studied. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
49. Notice of Retraction: Preparation of Cyanamide by Decomposition of Urea
- Author
-
Liu Yan and Lv Shuxiang
- Subjects
chemistry.chemical_compound ,Ammonia ,chemistry ,Transition metal ,Inorganic chemistry ,Urea ,Cyanamide ,Zeolite ,Decomposition ,Catalysis ,Refining (metallurgy) - Abstract
The paper mainly studies a new preparation technology of cyanamide. The auther designs a new technology: urea-cyanamide method. Different catalysts were used in the technoloy: ZSM-5 zeolite which are doped with transition metal cations selected from the Group A and Group B. The prepared catalysts were used in the decomposition of urea. Reaction conditions were as followed: with certain reaction temperature, reaction time, certain amount of catalyst, in the atmosphere of ammonia, so that the urea was decomposited into Cyanamide under normal pressure. This technology confirms atomic economical principle and it is low energy-consuming with little pollution and simple refining technology. Therefore it is a technology with good social and economic benefit. The difficulty of urea-cyanamide method is the selection of catalyst and high requirements for equipment.
- Published
- 2011
50. A combined experimental and computational study on the material properties of shape memory polyurethane
- Author
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Jinlian Hu, Fenglong Ji, Liu Yan, Ying Fan, and Cuili Zhang
- Subjects
Models, Molecular ,Materials science ,Hydrogen bond ,Organic Chemistry ,Intermolecular force ,Polyurethanes ,Thermodynamics ,Hydrogen Bonding ,Dynamic mechanical analysis ,Shape-memory alloy ,Molecular Dynamics Simulation ,Catalysis ,Dissociation (chemistry) ,Computer Science Applications ,Inorganic Chemistry ,Molecular dynamics ,Computational Theory and Mathematics ,Hardness ,Polymer chemistry ,Materials Testing ,Transition Temperature ,Physical and Theoretical Chemistry ,Glass transition ,Material properties - Abstract
A type of shape memory polyurethane with 60 wt% hard segments (SMPU60) was prepared. Its material properties were tested by dynamic mechanical analysis (DMA) and Instron, and simulated using fully atomistic molecular dynamics (MD). The glass transition temperature (T (g)) of SMPU60 determined by DMA is 316 K, which is slightly lower than that estimated through MD simulations (T (g) = 328 K) , showing the calculated T ( g ) is in good agreement with experimental data. A complex hydrogen bonding network was revealed with the calculation of radial distribution functions (RDFs). The C═O⋯H bond is the predominant hydrogen-bonding interaction. With increasing temperature, both the hydrogen bonding and the moduli decreased, and the dissociation of intermolecular hydrogen bonding induced the decrease of the moduli.
- Published
- 2011
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