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The cashew tree (Anacardium occidentale L.) is a tropical plant found widely in many Southeast Asian countries, including Thailand, and contains bioactive phenolic compounds with antioxidant activity. The natural antioxidants such as collagenase and tyrosinase inhibitors found in medicinal plants are promising agents in cosmetic products. This study evaluated the inhibitory activities of the collagenase and tyrosinase from cashew leaf extracts by developing and evaluating the stability of facial cream formulations. The ethanol (DEN), ethyl acetate (DEA) and distilled water (DDW) crude extracts of cashew leaves were investigated for their bioactive compound efficacy. The DDW extract had the highest yield (24.97%). All the extracts were investigated for their antioxidant activities. The DEN extract showed the highest DPPH radical-scavenging ability, ferric-reducing power and flavonoid compounds, which were 152.04 ± 2.40 mg gallic acid/g extract, 37.90 ± 1.07 mg gallic acid/g dry weight and 7.63 ± 0.07 mg quercetin/g dry weight, respectively. The DDW extract exhibited the highest potent activity, which was 111.00 ± 0.78 mg gallic acid/g dry weight in terms of phenolic content, while the DEN extract showed the highest tyrosinase inhibition at 0.100 mg/mL (46.97 ± 3.34%) and collagenase activity at 40 µg/mL. The results suggested that the ethanolic extracts from cashew leaves showed promise for use in skincare product development. Cosmeceutical formulations for skincare were prepared. The formula mixed with DEN extract and added to whitening and anti-aging skincare cream demonstrated good stability and physical properties. [ABSTRACT FROM AUTHOR]