1. Familial multiple sclerosis: does consanguinity have a role?
- Author
-
Al Jumah, M., Kojan, S., Al Khathaami, A., Al Abdulkaream, I., Al Blawi, M., and Jawhary, A.
- Subjects
MULTIPLE sclerosis ,CONSANGUINITY ,DISEASE prevalence ,CASE-control method ,SAUDI Arabians ,DISEASES - Abstract
Parental consanguinity (PC) may be a risk factor for familial multiple sclerosis (FMS) throughout inbred communities. The objective of this report was to estimate prevalence of FMS and rate of PC among FMS versus non-FMS patients. All Saudi MS patients were identified from our registry. The history of PC was analyzed as a case-control study. In total 141 MS patients were identified. Of these, 30 (21%) reported having at least one affected relative, 37.6% reported PC and 16% presented first-degree PC. In addition, FMS patients were more likely than non-FMS patients to report PC. In conclusion, FMS is prevalent among Saudi MS patients. MS patients with a history of PC were more likely to have FMS, suggesting a potential role of consanguinity. [ABSTRACT FROM PUBLISHER]
- Published
- 2011
- Full Text
- View/download PDF