1. 5-Carboxamido-1,3,2-dioxaphosphorinanes, potent inhibitors of MTP.
- Author
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Sulsky R, Robl JA, Biller SA, Harrity TW, Wetterau J, Connolly F, Jolibois K, and Kunselman L
- Subjects
- Amides chemistry, Amides pharmacology, Animals, Benzimidazoles chemistry, Benzimidazoles pharmacology, Cricetinae, Cyclic P-Oxides chemistry, Cyclic P-Oxides pharmacology, Humans, In Vitro Techniques, Male, Stereoisomerism, Structure-Activity Relationship, Amides chemical synthesis, Carrier Proteins antagonists & inhibitors, Cyclic P-Oxides chemical synthesis
- Abstract
5-Carboxamido-1,3,2-dioxaphosphorinanes have been identified as potent inhibitors of microsomal triglyceride-transfer protein. The 1,3,2-dioxaphosphorine functionality acted as a neutral and stable replacement for piperidine and piperidine N-oxide.
- Published
- 2004
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