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Objective: To investigate the effects of erythropoietin（EPO） combined with glutamine on gastrointestinal hormones,fecal bacteria and serum tumor necrosis factor-α（TNF-α), interleukin-6（IL-6） and intestinal fatty acid binding protein（i-FABP） levels in premature infants with necrotizing enterocolitis（NEC). Methods: 120 cases of NEC premature infants in Shandong Maternal and Child Health Hospital Affiliated to Shandong University and Affiliated Hospital of Xuzhou Medical University from December 2016 to December 2019 were selected, and they were randomly divided into EPO group（EPO treatment), glutamine group（glutamine treatment） and combination group（EPO combined with glutamine treatment), 40 cases in each group. The curative effect, gastrointestinal hormones,fecal bacterial indicators and serum i-FABP, TNF-α, IL-6 levels of the three groups were compared, and the incidence rate of adverse reactions and mortality of the three groups were recorded. Results: The total effective rate of the combination group was higher than that of the glutamine group and EPO group（P<0.05). After treatment, the TNF-α, IL-6 and i-FABP levels in the three groups were lower than those before treatment, and those in the combination group were lower than those in the glutamine group and EPO group（P<0.05). After treatment, the gastrin（MTL） and motilin（GAS） levels in the three groups were higher than those before treatment, and those in the combination group were higher than those in the glutamine group and EPO group（P<0.05). After treatment, the total number of bacteria,bacilli and cocci in the three groups were higher than those before treatment, and those in the combination group were higher than those in the glutamine group and EPO group（P<0.05). The incidence rate of adverse reactions and mortality in combination group were lower than those in glutamine group and EPO group（P<0.05). Conclusion: EPO combined with glutamine in the treatment of NEC premature infants can effectively improve gastrointestinal function, regulate intestinal flora, improve serum inflammatory factors and i-FABP levels,reduce the incidence of adverse reactions and case fatality, with a significant efficacy. [ABSTRACT FROM AUTHOR]

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