1. Association between serum fetuin-A levels, carotid artery stiffness, and intima-media thickness in patients with normotensive obstructive sleep apnea syndrome.
- Author
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Akyuz A, Oran M, Alpsoy S, Mutlu LC, Akkoyun DC, Guzel S, and Alp R
- Subjects
- Adult, Aged, Biomarkers blood, Blood Pressure physiology, Carotid Arteries physiopathology, Carotid Artery Diseases blood, Carotid Artery Diseases complications, Carotid Artery Diseases pathology, Female, Humans, Male, Middle Aged, Sleep Apnea, Obstructive blood, Carotid Arteries metabolism, Carotid Arteries pathology, Carotid Artery Diseases metabolism, Carotid Intima-Media Thickness, Sleep Apnea, Obstructive complications, Vascular Stiffness physiology, alpha-2-HS-Glycoprotein biosynthesis
- Abstract
Increased carotid intima-media thickness (cIMT) and stiffness, reflecting subclinical atherosclerosis, are associated with obstructive sleep apnea syndrome (OSAS). The relationship between serum fetuin-A, which inhibits ectopic calcification, and atherosclerosis is unclear. Therefore, we investigated the association between serum fetuin-A levels and carotid artery stiffness and cIMT in patients with normotensive OSAS (n = 50) and non-OSAS controls (n = 38). Compared with controls, there were lower fetuin-A levels (59.4 ± 6.5 vs 68.2 ± 5.8 ng/mL, P = .029), higher mean cIMT (0.73 ± 0.2 vs 0.63 ± 0.3 mm, P < .001), and greater stiffness (β) index (7.45 ± 0.9 vs 5.2 ± 0.7, P = .001) in the OSAS group. The cIMT and stiffness (β) index were inversely correlated with fetuin-A levels (r = -.324, P = .033; r = -.466, P < .001, respectively) and positively correlated with apnea hypopnea index (r = .498, P < .001; r = .422, P = .001, respectively) in the OSAS group. Decreased serum fetuin-A levels were associated with subclinical carotid atherosclerosis in patients with normotensive OSAS., (© The Author(s) 2013.)
- Published
- 2014
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