1. Cardiac Adverse Events in
- Author
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Kei, Kunimasa, Risa, Kamada, Toru, Oka, Makiko, Oboshi, Madoka, Kimura, Takako, Inoue, Motohiro, Tamiya, Tatsuya, Nishikawa, Taku, Yasui, Wataru, Shioyama, Kazumi, Nishino, Fumio, Imamura, Toru, Kumagai, and Masashi, Fujita
- Subjects
EGRF, epidermal growth factor receptor ,cardiac adverse events ,cardiac dysfunction ,LVIDs, left ventricular internal end-systolic diameter ,TR, tricuspid regurgitation ,ACE, angiotensin-converting enzyme ,LVIDd, left ventricular internal end-diastolic diameter ,EGFR mutations ,ARB, angiotensin II receptor blocker ,MR, mitral regurgitation ,PASP, pulmonary artery systolic pressure ,TKI, tyrosine kinase inhibitor ,VEGF, vascular endothelial growth factor ,non–small cell lung cancer ,CTCAE, common terminology criteria for adverse event ,NSCLC, non–small cell lung cancer ,osimertinib ,LVEF, left ventricular ejection fraction ,cardiovascular system ,NT-proBNP, N-terminal pro–B-type natriuretic peptide ,myocardial biopsy ,CTRCD, cancer therapeutics-related cardiac dysfunction ,AE, adverse event ,HER, human epidermal growth factor receptor ,Original Research - Abstract
Objectives The purpose of this study was to assess osimertinib-associated cardiac adverse events (AEs) in a real-world setting, using a retrospective single-center cohort study in Japan. Background Cases of osimertinib-associated cardiac AEs have been reported but remain poorly understood. Methods A total of 123 cases of advanced non–small cell lung cancer (NSCLC) with confirmed EGFR mutations who received osimertinib monotherapy from 2014 to 2019 at the Osaka International Cancer Institute (Osaka, Japan) were evaluated. Cardiac AEs were defined according to Common Terminology Criteria for Adverse Events (CTCAE) version 5.0. Changes in left ventricular ejection fraction (LVEF) and rates of cancer therapeutics-related cardiac dysfunction (CTRCD), defined as a ≥10 % absolute decline in LVEF from baseline to a value of, Central Illustration
- Published
- 2019