Search

Introduction: Stent thrombosis, an iatrogenic disease, is an important complication of percutaneous coronary intervention (PCI). The platelet to lymphocyte ratio (PLR) has been recently proposed to be a marker of thrombosis and inflammation, mainly in cancer patients. The aim of this study was to determine whether PLR in patients presenting with acute ST elevation myocardial infarction (STEMI) is predictive of the development of stent thrombosis.Patients and Methods: We retrospectively analyzed the clinical, hematologic, and angiographic data of total 201 patients (mean age 59.8±13.1 years, 3 out of 4 were males) who had undergone PCI for acute STEMI and a further control coronary angiography. 54 of them were diagnosed as stent thrombosis and formed the patient group and 147 patients matched with patient group in terms of age, gender, traditional coronary risk factors, stent implantation procedure, and stent type and length formed the control group in whom the stent implanted during primary PCI was found patent in the repeat coronary angiography.Results: The pre-procedural PLR was significantly higher in patients with stent thrombosis compared to patients without stent thrombosis (176±68 vs. 135±62; p, Giriş: İyatrojenik bir hastalık olan stent trombozu, perkutan koroner girişimin (PCI) önemli bir komplikasyonudur. Trombosit lenfosit oranının (PLR) son zamanlarda daha çok kanser hastalarında, tromboz ve inflamasyonun bir belirteci olduğu gösterilmiştir. Bu çalışmanın amacı akut ST yükselmeli miyokard infarktüsü (STYMİ) ile başvuran hastalarda PLR'nin stent trombozu gelişiminin bir öngördürücüsü olup olmadığını araştırmaktır.Hastalar ve Yöntem: Akut ST yükselmeli miyokard infarktüsü tanısıyla primer PCI yapılan ve daha sonra stabil anjina veya Akut koroner sendrom tanısıyla tekrar koroner anjiyografi yapılarak stent trombozu tanısı alan 54 olgu çalışmanın hasta grubunu oluştururken; bunlarla yaş, cinsiyet, koroner risk faktörleri, stent uygulama prosedürü ile stent tipi ve boyu bakımından benzer olup primer PCI sonrası yapılan koroner anjiyografide stenti patent bulunan 147 hasta kontrol grubunu oluşturdu. Toplam 201 hastanın (ortalama yaş 59,8±13,1 yıl, ¾'ü erkek) klinik, hematolojik ve anjiyografik verilerini retrospektif olarak inceledik.Bulgular: İşlem öncesi PLR, stent trombozu gelişen hastalarda gelişmeyenler ile karşılaştıldığında anlamlı olarak daha yüksekti (176±68'e karşı 135±62; p

BSTRACT Objective: the neutrophil/lymphocyte ratio (NLR), the platelet/lymphocyte ratio (PLR), and uric acid (UA) are inflammatory markers in cardiovascular disease. However, there are not enough data on infarct-related artery (IRA) patency in ST-segment elevation myocardial infarction (STEMI). We aimed to investigate the association of NLR, PLR, and UA with IRA patency before percutaneous coronary intervention (PCI) in STEMI. Methods: the study was designed as a retrospective study. Three hundred and twenty-four consecutive patients with STEMI were divided into two groups according to pre-PCI Thrombolysis in Myocardial Infarction flow grade (TIMI). Patients with a TIMI flow grade of into the spontaneous reperfusion (SR) group, while patients with TIMI flow grade of 0, 1 and 2 were placed into the non-SR group. the χ2 and independentsamples t-test, Mann-Whitney U test, multivariate logistic regression analysis, and receiver-operator characteristic (ROC) curve analysis were used for the statistical analysis. Results: PLR, NLR, and UA values in the SR group were lower than in the non-SR group (p190, UA>5.75 mg/dL, and NLR>4.2 predicted non-SR. the sensitivity and specificity of the association between low IRA TIMI flow grade and PLR were 88% and 84%, 72% and 66% for UA, and 74% and 44% for NLR, respectively. Conclusion: We determined that PLR and UA are novel predictors of IRA patency before PCI. We suggest that PLR and UA may be used in riskstratifying STEMI. (

Objective: We aimed to assess relationship between the severity of coronary atherosclerosis assessed by SYNTAX score (SS) and neutrophil to lymphocyte ratio (NLR) in patients with ST elevation myocardial infarction (STEMI. Methods: After accounting for exclusion criteria, a total of 291 patient with STEMI in whom primary percutaneous coronary intervention was performed were retrospectively included (216 male, 75 female; mean age 61.6+14.0 years). Total and differential leukocyte counts and other biochemical markers were measured at admission. Patients were categorized into tertiles on the basis of SS. Monitoring for major adverse cardiac events (MACEs) was performed during the in hospital follow-up period. Results: The SS high group leukocyte (p=0.009), neutrophil (p=0.008), NLR (p=0.048), peak troponin (p, Amaç: Biz bu çalışmada STEMİ hastalarında nötrofil lenfosit oranı (NLO) ve Syntax skoru (SS) ile değerlendirilen koroner aterosklerozun şiddeti arasındaki ilişkiyi ST yükselmeli miyokard infarktüsü (STEMİ)\'ünde değerlendirmeyi amaçladık. Yöntemler: Dışlama kriterleri sonrası primer perkütan koroner girişim uygulanan geriye dönük olarak toplamda 291 STEMI hastası çalışmaya alındı. (216 erkek,75 kadın, ortalama yaş 61,6±14,0 yıl). Toplam ve diferensiyel lökosit sayımı ve diğer biyokimyasal belirteçler hasta kabulünde alındı. Hastalar SS göre üç tertile ayrıldı. Majör istenmeyen kardiyak olaylar (MİKO) için izleme hastanede yatış döneminde yapıldı Bulgular: SSyüksek grup, lökosit (p=0,009), nötrofil (p=0,008), NLO (p=0,048), zirve troponin (p

Objective: The neutrophil/lymphocyte ratio (NLR), the platelet/lymphocyte ratio (PLR), and uric acid (UA) are inflammatory markers in cardiovascular disease. However, there are not enough data on infarct-related artery (IRA) patency in ST-segment elevation myocardial infarction (STEMI). We aimed to investigate the association of NLR, PLR, and UA with IRA patency before percutaneous coronary intervention (PCI) in STEMI. Methods: The study was designed as a retrospective study. Three hundred and twenty-four consecutive patients with STEMI were divided into two groups according to pre-PCI Thrombolysis in Myocardial Infarction flow grade (TIMI). Patients with a TIMI flow grade of into the spontaneous reperfusion (SR) group, while patients with TIMI flow grade of 0, 1 and 2 were placed into the non-SR group. The χ2 and independentsamples t-test, Mann-Whitney U test, multivariate logistic regression analysis, and receiver-operator characteristic (ROC) curve analysis were used for the statistical analysis. Results: PLR, NLR, and UA values in the SR group were lower than in the non-SR group (p190, UA>5.75 mg/dL, and NLR>4.2 predicted non-SR. The sensitivity and specificity of the association between low IRA TIMI flow grade and PLR were 88% and 84%, 72% and 66% for UA, and 74% and 44% for NLR, respectively. Conclusion: We determined that PLR and UA are novel predictors of IRA patency before PCI. We suggest that PLR and UA may be used in riskstratifying STEMI. (Anatol J Cardiol 2015; 15: 648-56)

PMID: 25537998 Abstract: Objective: The aim of this study was to evaluate the relationship between atrial electromechanical delay (EMD) measured with tissue Doppler imaging (TDI) and left atrial (LA) mechanical functions in patients with ischemic stroke and compare them with healthy controls. Methods: Thirty patients with ischemic stroke were enrolled into this cross-sectional, observational study. The control group consisted of 35 age- and gender-matched apparently healthy individuals patients. Acute cerebral infarcts of probable embolic origin were diagnosed via imaging and were confirmed by a neurologist. Echocardiographically, time intervals from the beginning of P wave to beginning of A wave from the lateral and septal mitral and right ventricular tricuspid annuli in TDI were recorded. The differences between these intervals gave the mechanical delays (inter- and intra-atrial). Left atrial (LA) volumes were measured using the biplane area-length method, and LA mechanical function parameters were calculated. Statistical analysis was performed using student s t-test, chi-squared test, and Pearson s test. Results: The laboratory and clinical characteristics were similar in the two groups. Increased left atrial EMD (21.36±10.38 ms versus 11.74±6.06 ms, p

Background/aim: The thrombolysis in myocardial infarction (TIMI) risk score (TRS), and the TIMI risk index (TRI) have been reported in coronary artery disease patients. We investigated whether admission TRI is associated with no-reflow (NRF) in patients undergoing primary percutaneous coronary intervention (p-PCI). Materials and methods: ST-segment elevation myocardial infarction (STEMI) patients treated with p-PCI were included in the study. TRI was calculated on admission using specified variables. We defined the angiographic NRF phenomenon as a coronary TIMI flow grade of ≤2 after the vessel was recanalized or a TIMI flow grade of 3 together with a final myocardial blush grade (MBG) of