1. Characterizing the inflammatory response to cardiopulmonary bypass in children.
- Author
-
Kozik DJ and Tweddell JS
- Subjects
- Age Factors, Animals, Anti-Inflammatory Agents therapeutic use, Aprotinin therapeutic use, Biocompatible Materials, Blood Coagulation physiology, Body Size, Child, Child, Preschool, Complement Activation, Cytokines physiology, Female, Humans, Hypoxia-Ischemia, Brain etiology, Infant, Infant, Newborn, Kallikreins physiology, Kinins physiology, Lymphocyte Activation, Male, Multiple Organ Failure etiology, Multiple Organ Failure physiopathology, Multiple Organ Failure prevention & control, Organ Specificity, Platelet Activation, Rats, Signal Transduction, Systemic Inflammatory Response Syndrome drug therapy, Systemic Inflammatory Response Syndrome physiopathology, Systemic Inflammatory Response Syndrome prevention & control, Systemic Inflammatory Response Syndrome therapy, Viscera physiopathology, Cardiopulmonary Bypass adverse effects, Inflammation Mediators physiology, Systemic Inflammatory Response Syndrome etiology
- Abstract
Cardiopulmonary bypass is known to trigger a global inflammatory response. Age-dependent differences in the inflammatory response, the increased susceptibility to injury of immature organ systems, and the larger extracorporeal circuit to patient size ratio results in greater susceptibility of younger and smaller patients to the damaging effects of cardiopulmonary bypass. In this review the components of the inflammatory response to cardiopulmonary bypass are reviewed with special reference to the pediatric age group, including the age-specific impact on organ systems. In addition the current and evolving strategies to prevent, limit, and treat the inflammatory response to cardiopulmonary bypass in children are examined.
- Published
- 2006
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