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Your search keyword '"Koumentaki E"' showing total 2 results
Start Over Author "Koumentaki E" Topic cardiopulmonary bypass
2 results on '"Koumentaki E"'

1. Penetration of linezolid into sternal bone of patients undergoing cardiopulmonary bypass surgery.

Author

Metallidis S, Nikolaidis J, Lazaraki G, Koumentaki E, Gogou V, Topsis D, Nikolaidis P, Charokopos N, and Theodoridis G

Subjects
Acetamides blood, Acetamides therapeutic use, Aged, Aged, 80 and over, Anti-Infective Agents blood, Anti-Infective Agents therapeutic use, Female, Humans, Infusions, Intravenous, Linezolid, Male, Osteomyelitis drug therapy, Oxazolidinones blood, Oxazolidinones therapeutic use, Sternum metabolism, Acetamides administration & dosage, Acetamides pharmacokinetics, Anti-Infective Agents administration & dosage, Anti-Infective Agents pharmacokinetics, Cardiopulmonary Bypass, Oxazolidinones administration & dosage, Oxazolidinones pharmacokinetics
Published
2007
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2. Penetration of moxifloxacin into sternal bone of patients undergoing routine cardiopulmonary bypass surgery.

Author

Metallidis S, Charokopos N, Nikolaidis J, Alexiadou E, Lazaraki G, Koumentaki E, Tsona A, Theodoridis G, and Nikolaidis P

Subjects
Aged, Anti-Bacterial Agents administration & dosage, Anti-Bacterial Agents blood, Anti-Bacterial Agents pharmacokinetics, Anti-Infective Agents administration & dosage, Anti-Infective Agents blood, Anti-Infective Agents pharmacokinetics, Aza Compounds administration & dosage, Aza Compounds blood, Chromatography, High Pressure Liquid, Female, Fluoroquinolones, Humans, Infusions, Intravenous, Male, Manubrium chemistry, Manubrium metabolism, Middle Aged, Moxifloxacin, Osteomyelitis drug therapy, Quinolines administration & dosage, Quinolines blood, Sternum chemistry, Aza Compounds pharmacokinetics, Cardiopulmonary Bypass, Quinolines pharmacokinetics, Sternum metabolism
Abstract

This study investigated plasma and bone concentrations of moxifloxacin following a single intravenous dose of 400mg to consider its potential role in the treatment of osteomyelitis. Eight patients who underwent routine cardiopulmonary bypass surgery were enrolled in the study. Plasma and bone samples were collected 2h and 5h after the end of infusion. High performance liquid chromatography was used for the determination of moxifloxacin concentrations. Mean plasma concentrations were 3.36 microg/mL and 2.93 microg/mL at 2h and 5h after the end of infusion. The concentrations in the body and manubrium of the sternal bone were 1.65 microg/g and 1.64 microg/g at 2h and 1.4 microg/g and 1.45 microg/g at 5h, respectively. Moxifloxacin showed good penetration into bone and could be considered for the treatment of osteomyelitis.

Published
2006
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