1. The routine use of platelet function tests in elective coronary artery bypass grafting: A prospective observational trial
- Author
-
Jelena Milin Lazovic, Emilija Petrovic, Marko Cubrilo, Svetozar Putnik, Nemanja Aleksic, Ilija Bilbija, Aleksandar Milojevic, Milos Matkovic, Valerija Peric, Tina Novakovic, Aleksandar Mikic, and Vladimir Tutus
- Subjects
Blood Platelets ,Pulmonary and Respiratory Medicine ,Transfusion rate ,Platelet Aggregation ,Platelet Function Tests ,Bypass grafting ,Observational Trial ,Population ,Postoperative Hemorrhage ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,Humans ,Medicine ,Platelet ,Coronary Artery Bypass ,education ,education.field_of_study ,business.industry ,3. Good health ,Platelet function test ,medicine.anatomical_structure ,030228 respiratory system ,Anesthesia ,Cryoprecipitate ,Surgery ,Cardiology and Cardiovascular Medicine ,business ,Platelet Aggregation Inhibitors ,Artery - Abstract
BACKGROUND Preoperative use of platelet function tests contributes to the decrease of re-intervention rate due to bleeding and the necessity of transfusion in coronary artery bypass grafting (CABG) patients. The aim was to investigate the predictive value and to justify routine preoperative use of multiple electrode aggregometry in these patients. METHODS A prospective observational trial which included 416 consecutive patients subjected to elective isolated CABG was conducted. The Multiplate® test was used to assess platelet function. Platelet function test results, postoperative blood loss, and transfusion requirements were compared between high and low bleeding risk patients. Receiver operating characteristic analysis was performed to assess the sensitivity and specificity of the arachidonic acid (ASPI) and adenosine di-phosphate high sensitive (ADPHS) tests. RESULTS ADPHS and ASPI test results significantly predicted total bleeding > 1000 ml (AUC, 0.685, p
- Published
- 2021
- Full Text
- View/download PDF