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Your search keyword '"Jon Renninger"' showing total 3 results
Start Over Author "Jon Renninger" Topic cardiology
3 results on '"Jon Renninger"'

3. An improved method for ECG recording in conscious dogs and monkeys: Pericardial lead placement

Author

Haisong Ju, Jason Payseur, Jon Renninger, Robert W. Coatney, Dennis Murphy, Lynne A. King, and XueJun Wu

Subjects
Pharmacology, medicine.medical_specialty, business.industry, Continuous monitoring, Improved method, Nonclinical safety, Toxicology, Signal, medicine.anatomical_structure, Internal medicine, Telemetry, Cardiology, medicine, Pericardium, cardiovascular diseases, Ecg signal, Lead Placement, business, Computer hardware
Abstract

Introduction Assessing the effects of new chemical entities on cardiovascular function is an essential component of nonclinical safety evaluation. Regulatory guidelines advocate the use of telemetry to evaluate drug effects on the cardiovascular system of animal including electrocardiogram (ECG) waveforms. Currently, standard method is to place ECG electrodes subcutaneously and the ECG signals have a suboptimal signal mainly due to movement artifacts. In order to improve and optimize the ECG signal and minimize movement artifacts, a model for continuous monitoring of the ECG in conscious, unrestrained animals by placing ECG electrodes on the pericardium was evaluated.

Published
2009

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