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Patient-level characteristics associated with survival for single ventricle heart disease following initial staged palliation have been described. However, the impact of peri-operative events on hospital discharge has not been examined. To characterize patient-level characteristics and peri-operative events that were associated with inability to be discharged after Stage 1 palliation (S1P). Analysis of the National Pediatric Cardiology Quality Improvement Collaborative Dataset including patients who underwent a S1P procedure between 2016 and 2019 (Norwood or Hybrid Stage 1 procedure). We examined patient-level characteristics and peri-operative events as possible predictors of inability to discharge after S1P. We constructed multivariate logistic regression models examining post-S1P discharge and in-hospital mortality, adjusting for covariates. 843 patients underwent a S1P and 717 (85%) patients were discharged home or remained inpatient until Stage 2 for social but not medical concerns. Moderate or greater pre-operative atrioventricular valve regurgitation (odds ratio (OR) 4.6, 95% confidence interval (CI) 1.8–12), presence of high-risk pre-operative adverse events (OR 1.5, 95%CI 1.0–2.3), peri-operative events: temporary dialysis (OR 5.4, 95%CI 1.5–18.9), cardiac catheterization or cardiac surgery (OR 2.9, 95%CI 1.8–4.6), sepsis (OR 2.7, 95%CI 1.2–6.2), junctional tachycardia (OR 2.6, 95%CI 1.0–6.3), necrotizing enterocolitis (OR 2.6, 95%CI 1.3–5.2), ECMO (OR 2.5, 95%CI 1.4–4.3), neurological injury (OR 2.1, 95%CI 1.1–4.1), and re-intubation (OR 1.8, 95%CI 1.1–2.9) were associated with inability to discharge after Stage 1. Cardiac anatomical factors, pre-operative adverse events, post-operative re-intubation, post-operative ECMO, infectious complications, and unplanned catheter or surgical re-interventions were associated with inability to discharge after S1P. These findings suggest that quality improvement efforts aimed at reducing these peri-operative events may improve Stage 1 survival and likelihood of discharge. [ABSTRACT FROM AUTHOR]