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1. The Greek study in the effects of colchicine in COvid-19 complications prevention (GRECCO-19 study): Rationale and study design

Author

Spyridon G. Deftereos, Gerasimos Siasos, Georgios Giannopoulos, Dimitrios A. Vrachatis, Christos Angelidis, Sotiria G. Giotaki, Panagiotis Gargalianos, Helen Giamarellou, Charalampos Gogos, Georgios Daikos, Marios Lazanas, Pagona Lagiou, Georgios Saroglou, Nikolaos Sipsas, Sotirios Tsiodras, Dimitrios Chatzigeorgiou, Nikolaos Moussas, Anastasia Kotanidou, Nikolaos Koulouris, Evangelos Oikonomou, Andreas Kaoukis, Charalampos Kossyvakis, Konstantinos Raisakis, Katerina Fountoulaki, Mihalis Comis, Dimitrios Tsiachris, Eleni Sarri, Andreas Theodorakis, Luis Martinez-Dolz, Jorge Sanz-Sánchez, Bernhard Reimers, Giulio G. Stefanini, Michael Cleman, Dimitrios Filippou, Christoforos D. Olympios, Vlasios N. Pyrgakis, John Goudevenos, George Hahalis, Theofilos M. Kolettis, Efstathios Iliodromitis, Dimitrios Tousoulis, and Christodoulos Stefanadis

Subjects
COVID, Cardiac, Troponin, CRP, Complications, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Objective: Colchicine has been utilized safely in a variety of cardiovascular clinical conditions. Among its potential mechanisms of action is the non-selective inhibition of NLRP3 inflammasome which is thought to be a major pathophysiologic component in the clinical course of patients with COVID-19. GRECCO-19 will be a prospective, randomized, open-labeled, controlled study to assess the effects of colchicine in COVID-19 complications prevention. Methods: Patients with laboratory confirmed SARS-CoV-2 infection (under RT PCR) and clinical picture that involves temperature >37.5 oC and at least two out of the: i. sustained coughing, ii. sustained throat pain, iii. Anosmia and/or ageusia, iv. fatigue/tiredness, v. PaO2

Published
2020
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2. The Greek study in the effects of colchicine in COvid-19 complications prevention (GRECCO-19 study): Rationale and study design

Author

Georgios Daikos, Vlasios Pyrgakis, Charalampos Gogos, Georgios Giannopoulos, George Hahalis, Nikolaos Koulouris, Georgios Saroglou, Anastasia Kotanidou, Eleni K. Sarri, Michael W. Cleman, Pagona Lagiou, Andreas Theodorakis, Mihalis Comis, Bernhard Reimers, Christos Angelidis, Sotiria G. Giotaki, Luis Martínez-Dolz, Katerina Fountoulaki, Theofilos M. Kolettis, Christoforos Olympios, Dimitrios Tousoulis, Marios Lazanas, Dimitrios A. Vrachatis, Spyridon Deftereos, Giulio G. Stefanini, Christodoulos Stefanadis, Sotirios Tsiodras, Helen Giamarellou, Efstathios K. Iliodromitis, Charalampos Kossyvakis, Dimitrios Chatzigeorgiou, Gerasimos Siasos, Nikolaos V. Sipsas, John A. Goudevenos, Nikolaos Moussas, Dimitrios Tsiachris, Panagiotis Gargalianos, Andreas Kaoukis, Dimitrios Filippou, Evangelos Oikonomou, Konstantinos Raisakis, and Jorge Sanz-Sánchez

Subjects
lcsh:Diseases of the circulatory (Cardiovascular) system, medicine.medical_specialty, Complications, Heart Diseases, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Pneumonia, Viral, Anosmia, MEDLINE, 030204 cardiovascular system & hematology, Article, Betacoronavirus, 03 medical and health sciences, chemistry.chemical_compound, COVID-19 Testing, 0302 clinical medicine, Throat, Internal medicine, medicine, Humans, Colchicine, 030212 general & internal medicine, Pandemics, Randomized Controlled Trials as Topic, COVID, Clinical Laboratory Techniques, SARS-CoV-2, business.industry, COVID-19, Ageusia, Troponin, Pathophysiology, medicine.anatomical_structure, chemistry, lcsh:RC666-701, Antirheumatic Agents, Symptom Assessment, medicine.symptom, Coronavirus Infections, CRP, Cardiology and Cardiovascular Medicine, business, Cardiac
Abstract

Objective Colchicine has been utilized safely in a variety of cardiovascular clinical conditions. Among its potential mechanisms of action is the non-selective inhibition of NLRP3 inflammasome which is thought to be a major pathophysiologic component in the clinical course of patients with COVID-19. GRECCO-19 will be a prospective, randomized, open-labeled, controlled study to assess the effects of colchicine in COVID-19 complications prevention. Methods Patients with laboratory confirmed SARS-CoV-2 infection (under RT PCR) and clinical picture that involves temperature >37.5 oC and at least two out of the: i. sustained coughing, ii. sustained throat pain, iii. Anosmia and/or ageusia, iv. fatigue/tiredness, v. PaO2, Graphical abstract Image 1

Published
2020
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