1. Preoperative radiochemotherapy in the treatment of advanced oral cancer: outcome of 276 patients.
- Author
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Klug C, Berzaczy D, Voracek M, Nell C, Ploder O, Millesi W, and Ewers R
- Subjects
- Adult, Aged, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Carcinoma, Squamous Cell pathology, Carcinoma, Squamous Cell surgery, Cohort Studies, Female, Fluorouracil therapeutic use, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Mitomycin therapeutic use, Mouth Neoplasms pathology, Mouth Neoplasms surgery, Neoplasm Recurrence, Local, Neoplasm Staging, Oropharyngeal Neoplasms drug therapy, Oropharyngeal Neoplasms pathology, Oropharyngeal Neoplasms radiotherapy, Oropharyngeal Neoplasms surgery, Retrospective Studies, Treatment Outcome, Carcinoma, Squamous Cell drug therapy, Carcinoma, Squamous Cell radiotherapy, Mouth Neoplasms drug therapy, Mouth Neoplasms radiotherapy, Neoadjuvant Therapy, Preoperative Care
- Abstract
Introduction: The aim of this study was to review survival and locoregional control in patients with advanced oral and oropharyngeal squamous cell carcinoma treated by multimodal therapy with preoperative radiochemotherapy and radical surgery., Material: Retrospective cohort study., Methods: Included in this analysis are 276 consecutive patients with UICC disease stages III and IV (T2: 13.0%; T3: 16.7%; T4: 70.3%; N0: 29.7%; N1: 20.3%; N2: 45.3%; N3: 4.7%; stage III: 16.3%; stage IV: 83.7%). All patients received preoperative radiochemotherapy (50Gy, Mitomycin and 5-Fluorouracil) and radical locoregional resection., Results: Median surveillance period was 101.4 months (24-202 months). 5-year overall survival probability was 53.9%. 5-year local control probability was 70.2%., Conclusion: These results underline the reliability of preoperative treatment of patients with oral and oropharyngeal cancer.
- Published
- 2009
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