11 results on '"Heicappell R"'
Search Results
2. Concomitment spread of a renal cell carcinoma beyond the kidney and a transitional cell carcinoma beyond the bladder.
- Author
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Straub B, Müller M, Schrader M, Goessl C, Heicappell R, and Miller K
- Subjects
- Humans, Male, Middle Aged, Carcinoma, Renal Cell secondary, Carcinoma, Transitional Cell secondary, Kidney Neoplasms pathology, Neoplasms, Multiple Primary pathology, Urinary Bladder Neoplasms pathology
- Abstract
We report the case of a 61-year-old man, with a rare combination of two advanced urological tumors: a concomitant spread of an adenocarcinoma beyond the kidney and a urothelial carcinoma beyond the bladder. We simultaneously performed a primary curative prostatovesiculectomy and a nephroureterectomy on the right with ileal neobladder. To our knowledge, a case report of concomitant spread of an adenocarcinoma beyond the kidney (pT3 pN0 M0 G3) and a urothelial carcinoma beyond the bladder (pT3a pN0 M0 G3) with subsequent curative therapy has thus far not been published. A combination of the two diseases described here is obviously a remarkable rarity.
- Published
- 2000
- Full Text
- View/download PDF
3. Long-term survival after surgery for recurrent advanced sarcomatoid renal carcinoma.
- Author
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Goessl C, Müller M, Heicappell R, Perez-Cantó A, and Miller K
- Subjects
- Aged, Humans, Magnetic Resonance Imaging methods, Male, Survivors, Carcinoma, Renal Cell surgery, Kidney Neoplasms surgery, Neoplasm Recurrence, Local surgery, Sarcoma surgery
- Published
- 1999
- Full Text
- View/download PDF
4. Cadherins in renal cell carcinoma.
- Author
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Heicappell R
- Subjects
- Adult, Cadherins physiology, Carcinoma, Renal Cell secondary, Embryo, Mammalian, Humans, Kidney cytology, Kidney pathology, Kidney physiology, Membrane Proteins analysis, Neoplasm Metastasis, Cadherins analysis, Carcinoma, Renal Cell pathology, Kidney Neoplasms pathology
- Abstract
Distant metastasis is the most predominant clinical problem in renal cell carcinoma. The first step of metastasis is detachment of tumor cells from the primary tumor and subsequent access to the circulation e.g. to lymph or blood vessels. Conceptually, detachment of tumor cells may be facilitated by loss of molecules that provide adhesion of normal cells, such as the cadherins. It has in fact been demonstrated that loss of E-cadherin is associated with invasion and metastasis in animal models and with an unfavorable prognosis in cancer patients. Four major cadherins have been demonstrated in normal kidney and renal cell carcinoma: N-cadherin, E-cadherin, ksp-cadherin, and cadherin 6. The particular role of each of these cadherins in pathogenesis of renal cell carcinoma is not completely understood at present.
- Published
- 1999
5. Telomerase activity in malignant and benign renal tumors.
- Author
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Müller M, Heicappell R, Krause H, Sachsinger J, Porsche C, and Miller K
- Subjects
- Adenoma, Oxyphilic enzymology, Angiomyolipoma enzymology, Enzyme-Linked Immunosorbent Assay, Humans, Polymerase Chain Reaction, Carcinoma, Renal Cell enzymology, Carcinoma, Transitional Cell enzymology, Kidney Neoplasms enzymology, Telomerase metabolism
- Abstract
Objectives: An important characteristic of malignant cells is their unlimited replicative potential, their immortality. In conferring this immortality, the enzyme telomerase is believed to play a crucial role. The detection of telomerase activity provides new knowledge regarding the biologic growth behavior of tumors and offers new diagnostic and therapeutic tools., Methods: In the present study the sensitive TRAP assay (telomeric repeat amplification protocol) was used to examine 44 malignant renal tumors and 8 benign tumors of the kidney and 52 specimens of normal renal tissue for telomerase activity., Results: Telomerase activity was detected in 63% of tissue samples obtained from histologically confirmed renal cell carcinomas. In cases of renal cell carcinoma restricted to the kidney, telomerase activity was detected in 58%. In cases in which tumor growth has progressed beyond the limits of the organ, telomerase activity was found in 69%. This stage dependence, however, did not reach statistical significance. No correlation to tumor grading was observed. Telomerase activity was found less frequent in chromophobe renal cell carcinomas. Neither the 8 benign renal tumors (4 oncocytomas and 4 angiomyolipomas) nor the specimens of normal kidney showed any evidence of telomerase activity., Conclusions: The proportion of remarkable slow-growing renal cell carcinomas showing telomerase activity is less than in other malignancies and may correlate with biologic growth behavior. Possible explanations include the presence of an alternative pathway, called ALT (alternative lengthening of telomeres) and an association with the loss or presence of the telomerase suppressor on the short arm of chromosome 3. Prolonged follow-up will be of special interest to determine whether lack of telomerase activity predicts favorable outcome.
- Published
- 1999
- Full Text
- View/download PDF
6. Beta-1 integrins in renal cell carcinoma--an immunohistochemical study.
- Author
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Heicappell R, Podlinski J, Mückshoff U, Buszello H, and Ackermann R
- Subjects
- Adult, Aged, Aged, 80 and over, Carcinoma, Renal Cell secondary, Female, Humans, Immunoenzyme Techniques, Kidney chemistry, Male, Middle Aged, Neoplasm Metastasis, Receptors, Fibronectin analysis, Receptors, Very Late Antigen analysis, Carcinoma, Renal Cell chemistry, Integrins analysis, Kidney Neoplasms chemistry, Neoplasm Proteins analysis
- Published
- 1994
7. Cell surface expression and serum levels of intercellular adhesion molecule-1 in renal cell carcinoma.
- Author
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Heicappell R, Podlinski J, Buszello H, and Ackermann R
- Subjects
- Adult, Aged, Aged, 80 and over, Carcinoma, Renal Cell pathology, Carcinoma, Renal Cell secondary, Cell Adhesion Molecules blood, Cell Membrane metabolism, Female, Humans, Immunohistochemistry, Intercellular Adhesion Molecule-1, Kidney Neoplasms blood, Kidney Neoplasms pathology, Male, Middle Aged, Carcinoma, Renal Cell metabolism, Cell Adhesion Molecules metabolism, Kidney Neoplasms metabolism
- Abstract
Intercellular adhesion molecule-1 (ICAM-1) is the natural ligand of the T-lymphocyte adhesion molecule LFA-1 (lymphocyte-function-associated antigen-1). ICAM-1 is involved in target cell recognition by T-lymphocytes, LAK cells and natural killer cells. The molecule has also been detected on a variety of normal cells and on human tumors. Renal cell carcinoma (RCC) is one of the few tumors that respond to immunotherapy, but clinical results are generally disappointing. We therefore analyzed, by immunohistochemistry, the expression of ICAM-1 in pairs of normal kidneys, RCC, and RCC metastases. Moreover, serum ICAM-1 was determined in RCC patients and compared with surface expression of cell-bound ICAM-1. Strong glomerular expression of ICAM-1 was observed in all specimens of normal kidney examined. Proximal tubuli were weakly stained in the majority of specimens. Of the tumors, 80% stained positive for ICAM-1. Although ICAM-1 was detected on the majority of extrarenal tumor specimens examined, staining was generally weaker in the metastases. Patients without metastases at initial presentation more frequently expressed ICAM-1 in their primary tumors than did patients with metastases. Levels of serum ICAM-1 (sICAM-1) were significantly higher in RCC patients than in controls with non-malignant renal diseases. Patients with an unfavorable prognosis, e.g. with advanced tumor stage or metastasis at initial presentation, had higher levels of sICAM-1 than patients with low-grade and/or low-stage tumors.(ABSTRACT TRUNCATED AT 250 WORDS)
- Published
- 1994
- Full Text
- View/download PDF
8. Detection of endogenous receptors for carbohydrate ligands in primary and metastatic human renal cell carcinoma.
- Author
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Buszello H, Gabius HJ, Ackermann R, and Heicappell R
- Subjects
- Acetylgalactosamine metabolism, Carcinoma, Renal Cell secondary, Female, Humans, Ligands, Male, Maltose metabolism, Middle Aged, Carbohydrate Metabolism, Carcinoma, Renal Cell metabolism, Kidney Neoplasms metabolism, Receptors, Cell Surface metabolism
- Abstract
Frozen sections of primary and metastatic human renal cell carcinoma (RCC) were analyzed for the expression of endogenous binding sites for carbohydrates. Fluorescent neoglycoproteins, carrying chemically linked carbohydrate residues on bovine serum albumin as a carrier protein, were applied to 44 primary tumor specimens. In the majority of specimens, accessible binding sites with specificity for maltose and N-acetylgalactosamine were detected. In specimens of normal kidney no specific binding of carbohydrate ligands was observed under these experimental conditions. Specimens of both the primary tumor and a metastasis were available in 10 cases. When the expression of specific binding sites of primary tumors and metastases was compared, the respective patterns were similar with no clear gain or loss of certain lectins in the metastases. We conclude that binding sites with specificity for maltose and N-acetylgalactosamine are present on human RCC and their corresponding metastases.
- Published
- 1993
- Full Text
- View/download PDF
9. Renal carcinoma (RC): regulation of antitumoral immune responses.
- Author
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Heicappell R and Ackermann R
- Subjects
- Carcinoma, Renal Cell immunology, Humans, Immunotherapy, Interferons immunology, Interleukins immunology, Kidney Neoplasms immunology, Lymphocyte Subsets immunology, Phagocytes immunology, Tumor Necrosis Factor-alpha immunology, Carcinoma, Renal Cell therapy, Kidney Neoplasms therapy
- Abstract
Advanced renal cell carcinoma (RCC) is almost completely resistant to conventional therapeutic approaches such as chemotherapy or radiotherapy. There is growing evidence that few patients may be cured from metastatic RCC by immunotherapy. Unlike 20 years ago, current immunotherapeutic regimens are set up with pure drugs, such as recombinant cytokines. Immunotherapy interferes with a complicated network of cellular immune effectors, e.g., T-lymphocytes, macrophages and natural killer cells. The activity of immune effectors cells is regulated and fine-tuned by a variety of cytokines, e.g., interleukins and interferons which are produced predominantly by the immune effector cells themselves. It is reasonable to expect that in the near future more patients will benefit from immunotherapy for RCC as the knowledge on regulation of the immune response to tumors is rapidly increasing.
- Published
- 1992
10. Rationale for immunotherapy of renal cell carcinoma.
- Author
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Heicappell R and Ackermann R
- Subjects
- Antineoplastic Agents therapeutic use, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Carcinoma, Renal Cell secondary, Combined Modality Therapy, Humans, Nephrectomy, Carcinoma, Renal Cell therapy, Cytokines therapeutic use, Immunotherapy, Active, Immunotherapy, Adoptive, Kidney Neoplasms therapy
- Abstract
Metastasis to distant organs is the principal cause of death from renal cell carcinoma (RCC). No commonly accepted therapy is available for disseminated RCC at present. Immunotherapy is a mode of therapy that either interferes with the immune system or makes use of drugs that have been derived from soluble mediators of the immune system. Several lines of evidence suggest that combinations of genetically engineered cytokines (e.g. interleukin-2 and interferon alpha) may be particularly active in the treatment of advanced RCC. There are two major rationales for considering immunotherapy for RCC: (1) there is currently no other therapy available, and (2) there is hardly any innovative approach besides immunotherapy. Still, immunotherapy is far from being a standard therapy for disseminated RCC.
- Published
- 1990
- Full Text
- View/download PDF
11. Cytostatic and cytolytic effects of human recombinant tumor necrosis factor on human renal cell carcinoma cell lines derived from a single surgical specimen.
- Author
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Heicappell R, Naito S, Ichinose Y, Creasey AA, Lin LS, and Fidler IJ
- Subjects
- Animals, Carcinoma, Renal Cell pathology, Cell Division drug effects, Cell Line, Cell Survival drug effects, Cells, Cultured, Glycoproteins pharmacology, Humans, Immunotherapy, Mice, Mice, Nude, Time Factors, Tumor Necrosis Factor-alpha, Carcinoma, Renal Cell therapy, Glycoproteins therapeutic use
- Abstract
The purpose of this study was to determine whether human tumor cell lines derived from a single tumor exhibit heterogeneous responses to the anti-tumor effects of human recombinant tumor necrosis factor (h-r-TNF). Several cell lines with different metastatic propensities have been established in culture from a single surgical specimen of a human renal cell carcinoma following different selection procedures in nude mice. The cell lines exhibited significant differences in in vitro susceptibilities to cytotoxic effects of TNF. Kinetic analysis of the interaction of TNF with susceptible renal carcinoma cells demonstrated that a short 30 min interaction of TNF with the cells is sufficient to produce significant lysis 72 hr later. One cycle of exposure of sensitive cells to h-r-TNF did not produce cells resistant to it, nor did the degree of sensitivity to h-r-TNF vary after one passage of the cells in nude mice. Tumor cell resistance to the effects of TNF did develop spontaneously after prolonged cultivation in culture. We conclude that tumor cells derived from a single human renal cell carcinoma exhibit a heterogeneous response to the cytotoxic effects of h-r-TNF.
- Published
- 1987
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