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Two cases of papillary carcinoma of the renal pelvis an d one of the ureter were pathohistologically studied. 1) Malign a ncy of them was graded to be III (according to Tsuji's classification) based on findings of tumor cells and infiltration. 2) Infiltration of neoplasti c cells were noted even at the outmost layer of the pelvic or ureteral wall In one case neoplastic cells were found in the vein. Generally, cells showed striking anaplasia, being different from normal transitional cells of the uroepithelium. 3) In the vicinity of the carcinomatous lesion, uroepithelium demon s trated metaplasia or even neoplastic change. As one of them had an associated tumor in the bladder, multicentric occurrence of uroepithelial tumor was here deeply impressed. By the way, the patient who had the tumor in the bladder had worked, for many years, being contaminated with chemicals of oil derivertives.